Product Description
Iguratimod (T-614) CAS#123663-49-0, a disease modifying anti-rheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Preclinical in vivo studies indicated that iguratimod was effective in an established adjuvant-induced arthritis model (ED40=3.6 mg/kg) in rats and also efficacious in a type II collagen-induced arthritis model in DBA/1J mice at 30 mg and 100 mg/kg.
Iguratimod, which was discovered by Toyama Pharmaceuticals and jointly co-developed with Eisai in Japan, was approved by the PMDA (Pharmaceuticals and Medical Devices Agency) of Japan on June 29, 2012 for the treatment of rheumatoid arthritis. This drug was also independently developed by Simcere Pharmaceutical Group and is marked as Iremod® in China. The drug exhibited inhibitory effects on granuloma inflammation, and was shown to be efficacious for the prevention of joint destruction in adjuvant arthritis.
In August 2011, China's State FDA approved Simcere Pharmaceutical Group's new drug application for iguratimod (T-614), a disease modifying anti-rheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Preclinical in vivo studies indicated that iguratimod was effective in an established adjuvant-induced arthritis model (ED40=3.6 mg/kg) in rats and also efficacious in a type II collagen-induced arthritis model in DBA/1J mice at 30 mg and 100 mg/kg.
Iguratimod Basic information
|
Product Name |
Iguratimod |
|
Synonyms |
IGURATIMOD; iguratimod( R&D); T 614; N-[7-methanesulfonamido-4-oxo-6-(phenoxy)chromen-3-yl]formamide; 3-(Formylamino)-7-(methylsulfonylamino)-6-phenoxy-4H-1-benzopyran-4-one; N-[3-(Formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]methanesulfonamide; IguratiMod (T 614); N-(7-(MethylsulfonaMido)-4-oxo-6-phenoxy-4H-chroMen-3-yl)forMaMide |
|
CAS |
123663-49-0 |
|
MF |
C17H14N2O6S |
|
MW |
374.37 |
|
EINECS |
808-127-0 |
|
Product Categories |
Pharmaceutical intermediate; Pharmaceuticals; API |
Iguratimod Chemical Properties
|
Melting point |
238.0 to 242.0°C |
|
Boiling point |
580.6±60.0°C (Predicted) |
|
Density |
1.52±0.1 g/cm3 (Predicted) |
|
Storage temp. |
Under inert gas (nitrogen or Argon) at 2-8°C |
|
Solubility |
DMSO (Slightly) |
|
Form |
Solid |
|
pka |
5.58±0.20 (Predicted) |
|
Color |
White to Off-White |
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