Product Basic Information
| Item | Details |
|---|---|
| Product Name | Hydrocortisone Acetate |
| CAS No. | 50-03-3 |
| Synonyms | Cortisol Acetate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate |
| Molecular Formula | C₂₃H₃₂O₆ |
| Molecular Weight | 404.50 |
| Appearance | White or almost white crystalline powder; Odorless |
| Specification | Pharmaceutical grade; Purity ≥97.0% (HPLC); Loss on drying ≤1.0%; Residue on ignition ≤0.1%; Compliant with heavy metal (≤10ppm) and solvent residue limits |
Product Core Functions & Applications
Hydrocortisone Acetate 50-03-3 exerts its pharmacological effects by binding to glucocorticoid receptors, regulating the expression of inflammatory mediators, and suppressing the body's excessive immune response. It is mainly applied in human pharmaceutical formulations (veterinary grade available upon request) across multiple administration routes:
1. Topical Formulations (Most Common Application)
Dermatology: Used in creams, ointments, lotions, and sprays to treat inflammatory and allergic skin conditions, such as:
Eczematous diseases (atopic dermatitis, contact dermatitis)
Psoriasis (mild to moderate)
Allergic dermatitis, seborrheic dermatitis
Insect bite reactions and pruritus
Its lipophilic acetate structure enhances skin penetration, improving local efficacy while reducing systemic absorption.
2. Ophthalmic Formulations
Formulated into eye drops or ointments to treat non-infectious inflammatory eye conditions, such as:
Conjunctivitis (allergic, chemical)
Iritis, uveitis (mild to moderate)
Post-operative ocular inflammation (to reduce edema and pain)
Note: Must not be used for infectious eye diseases (e.g., bacterial/viral keratitis) to avoid worsening infections.
3. Systemic & Local Injection Formulations
Injectables: Used in intra-articular injections to treat inflammatory joint diseases (e.g., rheumatoid arthritis, osteoarthritis) for localized pain relief and edema reduction; also used in intramuscular injections for short-term treatment of severe allergic reactions (e.g., urticaria, angioedema) when oral formulations are ineffective.
Rectal Formulations: Suppositories or enemas for treating ulcerative colitis and proctitis, targeting intestinal inflammation directly.
Quality & Safety Assurance
as a prescription steroid drug, requires strict quality control to ensure efficacy and minimize side effects:
Raw Material Sourcing: Uses high-purity starting materials (e.g., hydrocortisone) and adopts advanced synthesis routes (acetylation reaction) to avoid impurities (e.g., related steroids) that may cause adverse reactions.
Production Process: Produced in GMP-certified workshops, with strict control over reaction conditions, purification steps, and crystallization processes to ensure product stability, uniformity, and consistent potency.
Testing Protocols: Each batch undergoes comprehensive testing, including:
HPLC analysis for purity and related substance limits (single impurity ≤1.0%, total impurities ≤3.0%)
Melting point determination (216-224°C, with decomposition)
Heavy metal detection (Pb, Hg, Cd ≤10ppm)
Sterility testing (for injectable-grade raw materials)
Safety Reminders:
Long-term or large-dose use may cause systemic side effects (e.g., Cushing's syndrome, hyperglycemia, osteoporosis) and must be under medical supervision.
Topical use should avoid prolonged application on large areas or broken skin to prevent systemic absorption.
Sudden discontinuation is not recommended; dosage should be tapered gradually to avoid adrenal insufficiency.
Cooperation & Contact
We provide pharmaceutical-grade Hydrocortisone Acetate raw materials for manufacturers of topical, ophthalmic, injectable, and rectal formulations, with flexible supply capacities (from gram-level R&D samples to kilogram-level bulk orders). If you are a pharmaceutical enterprise, R&D institution, or formulator in need of this product, please contact us for:
Detailed specifications and pharmacopoeia compliance documents
Pricing and bulk order discounts
Sample requests and technical support (e.g., formulation guidance)
Contact Information:
Email: sales@huarongpharma.com
Phone/WhatsApp: +86 13751168070
We adhere to the principles of "quality first, compliance-oriented" and look forward to establishing long-term, mutually beneficial cooperative relationships with global partners!
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