Dehydroepiandrosterone (DHEA, CAS No.: 53-43-04) - Endogenous Steroid Precursor for Hormonal Balance & Wellness

As a professional supplier of pharmaceutical-grade and nutraceutical-grade steroid precursors, we provide high-purity Dehydroepiandrosterone (DHEA) that strictly complies with global standards (USP, EP, FCC). An endogenous C19 steroid hormone synthesized primarily by the adrenal cortex, DHEA acts as a precursor to both androgens (e.g., testosterone) and estrogens (e.g., estradiol). It is widely used in pharmaceutical formulations (for hormonal deficiency treatment) and nutraceutical products (for wellness support), offering versatile value in healthcare and anti-aging fields.

Product Basic Information

Core Functions & Applications

DHEA is a key "parent hormone" in human endocrine function-its levels peak in early adulthood (20-30 years) and decline with age. By serving as a precursor to sex hormones, it regulates hormonal balance and supports multiple physiological processes. It is primarily applied in pharmaceutical treatments and wellness products (no veterinary application for high-purity DHEA):

1. Pharmaceutical Field (Hormonal Deficiency Treatment)

Adrenal Insufficiency: Used in prescription formulations to supplement DHEA levels in patients with primary adrenal insufficiency (e.g., Addison's disease) or secondary adrenal insufficiency (e.g., pituitary disorders). It alleviates symptoms like fatigue, low libido, and mood disturbances caused by DHEA deficiency.

Postmenopausal Symptom Relief: Prescribed (in specific regions) to mitigate postmenopausal symptoms such as hot flashes, vaginal atrophy, and reduced bone density-by converting to estrogens and androgens to compensate for age-related hormonal declines.

Dosage Forms: Oral tablets, capsules, or transdermal patches (pharmaceutical-grade DHEA requires medical supervision due to hormonal activity).

2. Nutraceutical & Cosmetic Fields (Wellness & Anti-Aging)

Wellness Support: As a dietary supplement, DHEA is used to support:

Hormonal balance in aging adults (to counteract age-related DHEA decline).

Energy levels, mood, and cognitive function (anecdotal evidence, with ongoing clinical research).

Athletic performance (though some sports organizations restrict its use due to potential androgenic effects).

Key Note: Nutraceutical-grade DHEA is typically sold in low doses (10-50mg/day) and should be used per product guidelines.

Cosmetic Anti-Aging: Incorporated into anti-aging creams and serums for potential skin benefits:

Stimulates collagen production and reduces fine lines by supporting skin cell metabolism.

Improves skin elasticity and hydration (by regulating sebaceous gland function in some users).

Formulation Tip: Combined with antioxidants (e.g., vitamin E) to enhance stability and reduce skin irritation.

Quality & Safety Assurance

DHEA's hormonal activity and sensitivity to oxidation require strict quality control to ensure efficacy and safety:

Raw Material Sourcing: Derived from high-purity natural steroid precursors (e.g., plant-based stigmasterol) or advanced chemical synthesis. For pharmaceutical grade, raw materials undergo rigorous testing to eliminate contaminants (e.g., heavy metals, pesticide residues).

Production Process:

Pharmaceutical Grade: Manufactured in GMP-certified workshops with inert gas (nitrogen) protection during purification (e.g., column chromatography) and crystallization-preventing oxidation and ensuring batch-to-batch consistency.

Nutraceutical Grade: Processed with food-grade antioxidants and formulated into oil-based carriers (e.g., MCT oil) to improve solubility and stability for oral supplements.

Testing Protocols: Each batch undergoes comprehensive testing, including:

HPLC analysis for DHEA purity, related substances (e.g., androstenedione ≤2.0%), and oxidation by-products (e.g., ketones ≤1.0%).

Chiral purity testing (to confirm no inactive enantiomers, as DHEA is a single chiral compound).

Heavy metal (Pb, Hg, Cd) and microbial limit testing (critical for oral and cosmetic grades).

Safety Reminders:

Pharmaceutical Use: Must be prescribed by a healthcare provider-excessive doses may cause androgenic side effects (e.g., acne, hair growth in women) or estrogenic effects (e.g., breast tenderness in men). Contraindicated in patients with hormone-sensitive cancers (e.g., breast, prostate cancer) or liver disease.

Nutraceutical Use: Avoid use in pregnant/nursing women, children, and adolescents (hormonal systems are still developing). Long-term use (≥1 year) should be monitored by a healthcare professional.

Drug Interactions: May interact with corticosteroids (increased adrenal suppression risk) and insulin (potential blood glucose lowering effects)-consult a doctor before use with prescription medications.

Cooperation & Contact

We supply DHEA in both pharmaceutical grade (for prescription treatments) and nutraceutical grade (for supplements and cosmetics), with flexible capacities (from gram-level R&D samples to kilogram-level bulk orders). If you are a pharmaceutical manufacturer, nutraceutical brand, or cosmetic formulator, please contact us for:

Detailed grade specifications, purity certificates, and stability data.

Pricing, bulk discounts, and customized stabilization solutions (for nutraceutical/cosmetic clients).

Technical support (e.g., formulation compatibility, dosage guidance for different applications).

Contact Information:

Email: sales@huarongpharma.com

Phone/WhatsApp: +86 13751168070

We adhere to the principles of "purity first, safety-oriented" and look forward to establishing long-term, mutually beneficial partnerships with global clients in healthcare and wellness!

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