Product Description
Gatifloxacin, a fluoroquinolone antibiotic, is highly valued for its efficacy in combating various bacterial infections. The molecular formula of gatifloxacin is C₁₉H₂₂FN₃O₄, and it has a molecular weight of 375.40. It appears as a white to off-white crystalline powder.
It belongs to a class of antibiotics known for their broad-spectrum action. It showcases effectiveness against both gram-positive and gram-negative bacteria, making it an invaluable tool in combating a wide range of bacterial strains. In addition to its broad-spectrum nature, gatifloxacin also demonstrates utility in addressing specific mycobacterial infections.
The mechanism of action of gatifloxacin is based on its ability to inhibit bacterial DNA gyrase and topoisomerase IV. These enzymes are essential for bacterial DNA replication and transcription. By inhibiting these enzymes, gatifloxacin disrupts bacterial DNA synthesis, leading to the death of the bacteria. Gatifloxacin is effective against a wide range of gram-positive and gram-negative bacteria, including some that are resistant to other antibiotics.
After oral administration, gatifloxacin is rapidly absorbed from the gastrointestinal tract. It has good bioavailability, which means that a significant portion of the administered dose reaches the systemic circulation. Gatifloxacin is widely distributed throughout the body, including in tissues and body fluids. It can penetrate into cells and reach sites of infection. The drug is metabolized in the liver and excreted mainly through the kidneys. The elimination half-life of gatifloxacin is relatively long, which allows for once-daily dosing in many cases.
Clinical Applications
Respiratory Tract Infections
Gatifloxacin is effective in the treatment of respiratory tract infections such as pneumonia, bronchitis, and sinusitis. It can be used in both community-acquired and hospital-acquired infections.
Urinary Tract Infections
It is also used in the treatment of urinary tract infections, including cystitis and pyelonephritis. Gatifloxacin can reach high concentrations in the urine, making it effective against bacteria that cause these infections.
Skin and Soft Tissue Infections
For skin and soft tissue infections, gatifloxacin can be used topically or systemically, depending on the severity of the infection.
Ocular Infections
In some cases, gatifloxacin is formulated as an ophthalmic solution for the treatment of ocular infections such as conjunctivitis and keratitis.
The most common side effects include nausea, vomiting, diarrhea, headache, and dizziness. Less frequently, it can cause more serious adverse effects such as allergic reactions, liver toxicity, and QT prolongation. QT prolongation can increase the risk of ventricular arrhythmias, especially in patients with underlying heart conditions or those taking other medications that can prolong the QT interval. Therefore, caution should be exercised when prescribing gatifloxacin to these patients.
Product Details
|
Items |
Standard |
Result |
|
Appearance |
Off-white or yellowish crystalline powder |
Complies |
|
Water |
4.0~8.0% |
4.7% |
|
Residue on ignition |
≤0.2% |
0.05% |
|
Heavy metal |
≤20PPM |
Complies |
|
Purity |
≥98.5% |
99.59% |
|
Any single unknown impurity |
≤0.5% |
0.25% |
|
Total impurities |
≤1.0% |
0.41% |
|
Assay |
≥98.5% |
99.2% |
|
Conclusion |
The product complies enterprise standard |
|
Packaging
|
Weight |
Package |
|
<25KG |
By foil-alum bag/pap/bottle |
|
≥25kg |
Package: 25kg/drum/bag or as your request |
FAQ
Q1. Can I get some samples?
A1. Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2. How to start orders or make payments?
A2. Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment we can accept T/T, LC or DP.
Q3. How to confirm the Product Quality before placing orders?
A3. We will provide COA for your check or sent sample for test.
Q4. What's your packing size?
A4. Our regular packing is 25kg/drum.
Q5. How about delivery leadtime?
A5. For ready cargo, we can arrange to dispatch the cargo as soon as received the payment. If not stock available, the production will takes 2-3 weeks.
Q6. Is there a discount?
A6. We provide better price for larger quantity.
Q7. How do you treat quality complaint?
A7. First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8. How to contact us?
A8. You can choose your interested products and send inquiry to us at eric@huarongpharma.com.
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