Praziquantel | CAS NO.55268-74-1

Praziquantel is a synthetic anthelmintic drug that is widely used to combat a variety of parasitic worms. It was first introduced in the 1970s and has since become one of the most important drugs for the treatment of schistosomiasis, liver flukes, tapeworms, and other parasitic infections. The drug is available in different forms, including tablets, capsules, and suspensions, making it accessible for administration to patients of different ages and conditions.

Chemically, praziquantel is a white to off-white crystalline powder. Its molecular formula is C₁₉H₂₄N₂O₂, and it has a molecular weight of 312.41. The compound is sparingly soluble in water but dissolves well in organic solvents such as ethanol and chloroform.

The mechanism of action of praziquantel is complex and involves multiple steps. The drug acts on the parasite's cell membrane, causing it to become permeable and allowing calcium ions to enter the cell. This influx of calcium ions leads to muscle contraction and paralysis of the parasite. Additionally, praziquantel may also interfere with the parasite's energy metabolism and disrupt its reproductive cycle. As a result, the parasite is unable to survive and is eliminated from the body.

Praziquantel is the drug of choice for the treatment of schistosomiasis, a parasitic disease caused by trematodes of the genus Schistosoma. The disease is prevalent in many parts of the world, especially in tropical and subtropical regions. Praziquantel is effective against all species of Schistosoma and can be used to treat both acute and chronic infections.

Praziquantel is also used to treat infections caused by liver flukes, such as Opisthorchis viverrini and Clonorchis sinensis. These parasites can cause liver damage and increase the risk of developing liver cancer. Praziquantel is effective in killing the adult flukes and reducing the severity of the infection.

Infections caused by tapeworms, such as Taenia solium and Taenia saginata, can be treated with praziquantel. The drug is effective in killing the adult worms and preventing the spread of the infection.

Praziquantel may also be used to treat other parasitic infections, such as echinococcosis and cysticercosis. However, the use of praziquantel in these conditions is often combined with other drugs or treatment modalities.

The most common side effects include headache, dizziness, nausea, vomiting, and abdominal pain. These side effects are usually mild and transient and resolve on their own within a few days. In rare cases, more serious side effects such as allergic reactions, liver damage, and neurological disorders may occur. Therefore, it is important to use praziquantel under the supervision of a healthcare professional and to follow the recommended dosage and administration instructions.

Q1. Can I get some samples?

A1. Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2. How to start orders or make payments?

A2. Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment we can accept T/T, LC or DP.

Q3. How to confirm the Product Quality before placing orders?

A3. We will provide COA for your check or sent sample for test.

Q4. What's your packing size?

A4. Our regular packing is 25kg/drum.

Q5. How about delivery leadtime?

A5. For ready cargo, we can arrange to dispatch the cargo as soon as received the payment. If not stock available, the production will takes 2-3 weeks.

Q6. Is there a discount?

A6. We provide better price for larger quantity.

Q7. How do you treat quality complaint?

A7. First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

Q8. How to contact us?

A8. You can choose your interested products and send inquiry to us at eric@huarongpharma.com.

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