Product Description
Gatifloxacin mesylate is a synthetic broad-spectrum antibacterial agent. It belongs to the fourth generation of fluoroquinolone antibiotics. This compound is known for its potent antibacterial activity against a wide range of gram-positive and gram-negative bacteria.
Gatifloxacin mesylate works by inhibiting the activity of bacterial DNA gyrase and topoisomerase IV. These enzymes are essential for bacterial DNA replication and transcription. By inhibiting these enzymes, gatifloxacin mesylate disrupts bacterial DNA synthesis, leading to cell death.
This mechanism of action makes gatifloxacin mesylate effective against a wide range of bacteria, including those that are resistant to other antibiotics. It has activity against common pathogens such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.
After oral administration, gatifloxacin mesylate is rapidly absorbed from the gastrointestinal tract. It has good bioavailability, with approximately 96% of the drug being absorbed. Peak plasma concentrations are reached within 1 to 2 hours.
The drug is widely distributed throughout the body, with high concentrations achieved in tissues such as the lungs, kidneys, prostate, and skin. It can penetrate into cells and reach sites of infection, making it effective against intracellular pathogens.
Gatifloxacin mesylate is metabolized in the liver by cytochrome P450 enzymes. The major metabolite is desmethyl gatifloxacin, which also has antibacterial activity. The drug and its metabolites are excreted primarily in the urine.
Gatifloxacin mesylate is effective in the treatment of respiratory tract infections such as pneumonia, bronchitis, and sinusitis. It is particularly useful in cases where the infection is caused by bacteria that are resistant to other antibiotics.
It is also used in the treatment of urinary tract infections, including cystitis and pyelonephritis. The drug's high concentration in the kidneys and urine makes it an effective treatment option for these infections.
Gatifloxacin mesylate is available in ophthalmic formulations for the treatment of ocular infections such as conjunctivitis and keratitis. It has good penetration into the eye tissues and provides effective antibacterial activity.
Skin and Soft Tissue Infections: It can be used to treat skin and soft tissue infections such as cellulitis, abscesses, and wound infections. The broad-spectrum activity of gatifloxacin mesylate makes it effective against a variety of bacteria that can cause these infections.
The most common side effects include nausea, vomiting, diarrhea, headache, and dizziness. Less common but more serious side effects can occur, such as tendon rupture, hypoglycemia, and QT prolongation.
Tendon rupture is a rare but serious complication that can occur with fluoroquinolone antibiotics. It is more likely to occur in elderly patients, those taking corticosteroids, and those with a history of tendon disorders. Hypoglycemia can occur in diabetic patients taking gatifloxacin mesylate, especially those taking oral hypoglycemic agents. QT prolongation can lead to serious cardiac arrhythmias and is a concern in patients with underlying heart disease or those taking other medications that can prolong the QT interval.
FAQ
Q1. Can I get some samples?
A1. Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2. How to start orders or make payments?
A2. Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment we can accept T/T, LC or DP.
Q3. How to confirm the Product Quality before placing orders?
A3. We will provide COA for your check or sent sample for test.
Q4. What's your packing size?
A4. our regular packing is 25kg/drum.
Q5. How about delivery leadtime?
A5. For ready cargo, we can arrange to dispatch the cargo as soon as received the payment. If not stock available, the production will takes 2-3 weeks.
Q6. Is there a discount?
A6. We provide better price for larger quantity.
Q7. How do you treat quality complaint?
A7. First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8. How to contact us?
A8. You can choose your interested products and send inquiry to us at eric@huarongpharma.com.
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