Product Basic Information
| Item | Details |
|---|---|
| Product Name | Hydrocortisone |
| CAS No. | 50-23-7 |
| Synonyms | Cortisol; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione |
| Molecular Formula | C₂₁H₃₀O₅ |
| Molecular Weight | 362.46 |
| Appearance | White or almost white crystalline powder; Odorless |
| Specification | Pharmaceutical grade; Purity ≥97.0% (HPLC); Loss on drying ≤0.5%; Residue on ignition ≤0.1%; Heavy metals ≤10ppm; Compliant with solvent residue limits |
Product Core Functions & Applications
Hydrocortisone exerts its effects by binding to glucocorticoid receptors in the body, regulating the synthesis of inflammatory factors and maintaining normal adrenal hormone levels. It is mainly applied in human pharmaceutical formulations (veterinary grade available upon request) across diverse administration routes:
1. Systemic Therapy (Oral/Injectable)
Hormone Replacement Therapy: First-line medication for adrenal insufficiency (e.g., Addison's disease, congenital adrenal hyperplasia), used to supplement the body's deficient cortisol and maintain normal physiological functions (e.g., blood glucose regulation, electrolyte balance).
Severe Inflammatory/Allergic Conditions: Treats life-threatening or severe diseases, such as:
Severe allergic reactions (anaphylactic shock, angioedema)
Autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis)
Severe asthma, acute respiratory distress syndrome (ARDS)
Dosage forms: Oral tablets (for long-term replacement) and injectable solutions (for emergency or severe cases, via intravenous/intramuscular administration).
2. Topical Therapy
Dermatology: Formulated into creams, ointments, and lotions to treat mild-to-moderate inflammatory skin conditions, including:
Atopic dermatitis, contact dermatitis
Seborrheic dermatitis, psoriasis (localized lesions)
Insect bites, pruritus
Compared to its acetate derivative, Hydrocortisone has milder skin penetration, making it suitable for sensitive areas (e.g., face, groin) and pediatric use.
3. Ophthalmic & Mucosal Therapy
Ophthalmology: Eye drops/ointments for non-infectious ocular inflammation (e.g., allergic conjunctivitis, mild uveitis), relieving redness, edema, and itching.
Mucosal Use: Nasal sprays for allergic rhinitis (reducing nasal congestion and sneezing) or rectal suppositories/enemas for ulcerative colitis (targeting intestinal mucosal inflammation).
Quality & Safety Assurance
Hydrocortisone, as a prescription steroid and hormone replacement drug, requires strict quality control to ensure efficacy and safety:
Raw Material Sourcing: Uses high-purity starting materials (e.g., pregnenolone derivatives) and advanced biosynthesis or chemical synthesis techniques to avoid impurities (e.g., related steroids) that may cause adverse reactions.
Production Process: Manufactured in GMP-certified workshops, with strict control over reaction parameters, purification steps, and crystallization processes to ensure product stability, uniformity, and consistent potency.
Testing Protocols: Each batch undergoes comprehensive testing, including:
HPLC analysis for purity and related substances (single impurity ≤1.0%, total impurities ≤3.0%)
Melting point determination (212-222°C, with decomposition)
Heavy metal (Pb, Hg, Cd) and microbial limit testing
Sterility testing (for injectable-grade raw materials)
Safety Reminders:
Long-term systemic use may cause Cushing's syndrome (moon face, weight gain), hyperglycemia, or osteoporosis-must be prescribed and monitored by a doctor, with dosage tapered gradually when discontinuing.
Topical use should avoid prolonged application on broken skin to reduce systemic absorption.
Patients with infections (e.g., active tuberculosis, severe bacterial infections) require concurrent antimicrobial treatment when using Hydrocortisone.
Cooperation & Contact
We supply pharmaceutical-grade Hydrocortisone raw materials for manufacturers of oral, injectable, topical, and ophthalmic formulations, with flexible capacities (from gram-level R&D samples to kilogram-level bulk orders). If you are a pharmaceutical enterprise, R&D institution, or formulator in need of this product, please contact us for:
Detailed pharmacopoeia compliance documents
Pricing, bulk discounts, and sample requests
Technical support (e.g., formulation compatibility guidance)
Contact Information:
Email: sales@huarongpharma.com
Phone/WhatsApp: +86 13751168070
We adhere to "quality first, compliance-oriented" principles and look forward to building long-term, mutually beneficial partnerships with global clients!
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