Prednisone Acetate (CAS No.: 125-10-0) - Potent Glucocorticoid for Anti-Inflammatory & Immunosuppressive Therapy

As a professional supplier of pharmaceutical-grade steroid active ingredients, we provide high-purity Prednisone Acetate that strictly complies with global pharmacopoeia standards (USP, EP, BP, CP). A synthetic glucocorticoid derivative of prednisone, it exhibits stronger anti-inflammatory activity than endogenous cortisol and enhanced stability in formulations-making it a core medication for treating a wide range of inflammatory, allergic, and autoimmune diseases in humans.

Product Basic Information

Product Core Functions & Applications

Prednisone Acetate exerts its pharmacological effects by first being converted to prednisolone (its active metabolite) in the liver, then binding to glucocorticoid receptors to inhibit the synthesis of inflammatory mediators (e.g., prostaglandins, cytokines) and suppress abnormal immune responses. Its key advantages-strong anti-inflammatory activity (≈4x that of cortisol) and weak mineralocorticoid effects (minimal impact on water-electrolyte balance)-make it suitable for both systemic and local therapy. It is exclusively used in human pharmaceutical formulations (veterinary grade available upon request):

1. Systemic Therapy (Oral/Injectable)

Autoimmune Diseases: First-line treatment for conditions like systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren's syndrome, and polymyositis, reducing immune-mediated tissue damage and symptom severity.

Severe Inflammatory Conditions: Manages acute asthma exacerbations, chronic obstructive pulmonary disease (COPD) flare-ups, and inflammatory bowel disease (Crohn's disease, ulcerative colitis) to control acute inflammation and prevent complications.

Hematological & Oncological Disorders: Used in treating immune thrombocytopenic purpura (ITP), autoimmune hemolytic anemia, and as an adjuvant in leukemia/lymphoma chemotherapy (to reduce inflammation and chemotherapy-induced nausea).

Dosage Forms: Oral tablets (for long-term maintenance, standard dose 5-60mg/day) and injectable suspensions (for patients unable to take oral medications or severe cases, via intramuscular/intra-articular administration).

2. Local Therapy (Topical/Ophthalmic)

Dermatology: Formulated into creams, ointments, and lotions for moderate-to-severe inflammatory skin diseases, such as:

Atopic dermatitis, contact dermatitis (unresponsive to milder steroids).

Psoriasis (plaque-type), bullous pemphigoid, and seborrheic dermatitis.

Its acetate ester structure enhances skin penetration and stability compared to unesterified prednisone.

Ophthalmology: Eye drops or ointments for non-infectious ocular inflammation, including uveitis, keratitis (non-infectious), and post-cataract surgery inflammation-relieving redness, edema, and pain while preventing scarring.

Quality & Safety Assurance

Prednisone Acetate, as a potent prescription steroid, requires rigorous quality control to ensure efficacy and minimize safety risks:

Raw Material Sourcing: Uses high-purity steroid precursors (e.g., cortisone acetate) and advanced chemical synthesis (introducing a double bond at C1-2 to enhance activity) to avoid impurities (e.g., prednisone, prednisolone) that may affect potency or cause inconsistent metabolism.

Production Process: Manufactured in GMP-certified workshops, with strict control over acetylation reaction conditions, purification (e.g., column chromatography), and crystallization to ensure product stability, uniformity, and consistent conversion to prednisolone in vivo.

Testing Protocols: Each batch undergoes comprehensive testing, including:

HPLC analysis for purity and related substances (single impurity ≤1.0%, total impurities ≤3.0%).

Melting point determination (235-242°C, with decomposition).

Specific optical rotation (+158° to +165°, in dioxane).

Heavy metal (Pb, Hg, Cd) and microbial limit testing (critical for topical/ophthalmic grades).

Sterility testing (for injectable-grade raw materials).

Safety Reminders:

Systemic Side Effects: Long-term use may cause Cushing's syndrome (moon face, truncal obesity), hyperglycemia, osteoporosis, or immunosuppression-must be prescribed by a doctor, with dosage tapered gradually to avoid adrenal insufficiency.

Local Side Effects: Topical use on large areas or broken skin may lead to systemic absorption; avoid prolonged use on the face or intertriginous areas (e.g., armpits, groin) to reduce skin atrophy, striae, or hypopigmentation.

Contraindications: Patients with active infections (e.g., untreated tuberculosis, severe bacterial/viral infections) unless combined with antimicrobial therapy; hypersensitivity to glucocorticoids.

Cooperation & Contact

We supply pharmaceutical-grade Prednisone Acetate raw materials for manufacturers of oral, injectable, topical, and ophthalmic formulations, with flexible capacities (from gram-level R&D samples to kilogram-level bulk orders). If you are a pharmaceutical enterprise, R&D institution, or formulator in need of this product, please contact us for:

Detailed pharmacopoeia compliance documents (e.g., USP/EP monograph confirmation).

Pricing, bulk order discounts, and sample requests.

Technical support (e.g., formulation compatibility, stability guidance for esterified steroids).

Contact Information:

Email: sales@huarongpharma.com

Phone/WhatsApp: +86 13751168070

We adhere to the principles of "quality first, compliance-oriented" and look forward to establishing long-term, mutually beneficial cooperative relationships with global partners!

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