Hey there! As a supplier of Chloromycetin (CAS 56 - 75 - 7), I'm super stoked to chat about its physical properties. Chloromycetin, also known as chloramphenicol, is a well - known antibiotic that's been around for quite a while. Let's dig into what makes it tick in the physical world.
Appearance
First off, let's talk about how Chloromycetin looks. It's a white to grayish - white, fine, crystalline powder. When you see it up close, it's got this really clean and almost powdery - soft look. It's not like some other substances that might have a rough or clumpy appearance. The crystals are pretty uniform in size, which is a sign of good quality. This fine powder form makes it easy to handle in various pharmaceutical processes, whether it's being mixed into a solution or made into tablets.
Solubility
Solubility is a big deal when it comes to drugs. Chloromycetin has some interesting solubility properties. It's sparingly soluble in water. What does that mean? Well, it doesn't dissolve really well in water. You can't just dump a whole bunch of it into a glass of water and expect it to disappear. Usually, only a small amount will dissolve. For example, at 25°C, only about 2.5 g of Chloromycetin will dissolve in 100 mL of water.
On the other hand, it's quite soluble in organic solvents like ethanol, acetone, and chloroform. This solubility in organic solvents is really useful in the pharmaceutical industry. It allows for the preparation of different formulations. For instance, in some cases, it can be dissolved in ethanol to create a liquid dosage form that's easier to administer to patients.
Melting Point
The melting point of Chloromycetin is another important physical property. It melts at around 149 - 153°C. This relatively high melting point is a sign of its stability. It means that under normal storage conditions, it's not going to melt and turn into a gooey mess. When you're manufacturing drugs, you need substances that can withstand a certain amount of heat during the production process, and Chloromycetin fits the bill.
Density
Density gives us an idea of how much mass is packed into a certain volume. The density of Chloromycetin is about 1.4 g/cm³. This density value is important for things like packaging and shipping. It helps in calculating how much space a certain amount of the substance will take up. Also, in the manufacturing process, density can affect how the powder flows and mixes with other ingredients.
Optical Activity
Chloromycetin is an optically active compound. It has two chiral centers, which means it can exist in different stereoisomeric forms. The biologically active form is the D - threo isomer. This optical activity is crucial because only the correct isomer has the desired antibiotic effect. The wrong isomer might not work at all or could even have negative side effects. Scientists have to be really careful during the synthesis process to make sure they're getting the right isomer.
Stability
Chloromycetin is relatively stable under normal conditions. It can be stored at room temperature for a reasonable amount of time without significant degradation. However, it's sensitive to light and moisture. Exposure to light can cause it to break down over time, so it's usually stored in dark containers. Moisture can also lead to chemical changes in the compound, which is why it's important to keep it in a dry environment.
Now, let's talk a bit about how Chloromycetin compares to some other compounds. For example, H-GLU-ALA-OH（Dipeptiven) CAS# 21064-18-6 is a dipeptide used in food supplements. Unlike Chloromycetin, it has different solubility and stability requirements. It's designed to be used in the food industry, so its physical properties are tailored to that application.
Another comparison can be made with Isotretinoin CAS 4759-48-2. Isotretinoin is used for treating severe acne. It has a different chemical structure and thus different physical properties. For example, its solubility and melting point are quite different from Chloromycetin. These differences are what make each compound suitable for its specific medical use.
Sarafloxacin | CAS# 98105-99-8 is an antibiotic like Chloromycetin, but they have distinct physical characteristics. Sarafloxacin might have a different solubility profile or melting point, which affects how it's formulated and used in veterinary medicine.
In the pharmaceutical industry, understanding these physical properties is key. They determine how a drug is made, stored, and administered. For us as a supplier of Chloromycetin, we need to ensure that we're providing a high - quality product that meets all the necessary physical property standards. We have strict quality control measures in place to make sure the Chloromycetin we supply has the right appearance, solubility, melting point, and other properties.
If you're in the market for Chloromycetin or have any questions about its physical properties or how it can be used in your formulations, don't hesitate to reach out. We're here to help you with all your Chloromycetin needs and can have a detailed discussion about how it can fit into your projects. Whether you're a pharmaceutical manufacturer or involved in research, we can provide you with the best - quality Chloromycetin that meets your specific requirements.
References
- Martindale: The Complete Drug Reference
- The Merck Index