Lincomycin Hydrochloride (CAS No.: 859-18-7) - Lincosamide Antibacterial for Gram-Positive & Anaerobic Infections

As a professional supplier of pharmaceutical-grade and veterinary-grade antibacterial active ingredients, we provide high-purity Lincomycin Hydrochloride that strictly complies with global pharmacopoeia standards (USP, EP, BP, CP). A natural lincosamide antibiotic derived from Streptomyces lincolnensis, it exhibits potent activity against Gram-positive bacteria and anaerobes-serving as a critical therapeutic option for infections in humans (especially penicillin-allergic patients) and animals. Its well-defined spectrum and clinical efficacy make it widely used in both healthcare and animal health fields.

Product Basic Information

Core Functions & Applications

Lincomycin Hydrochloride exerts its bacteriostatic effect by binding to the 50S subunit of bacterial ribosomes, interfering with peptide chain elongation and thus inhibiting bacterial protein synthesis. At high concentrations (or against susceptible strains), it may exhibit bactericidal activity. Its spectrum is focused on Gram-positive cocci (e.g., staphylococci, streptococci) and anaerobes-with no activity against Gram-negative bacteria. It is applied in both human medicine and veterinary practice:

1. Human Pharmaceutical Field

1.1 Skin & Soft Tissue Infections

Primary Indication: Treats infections caused by susceptible Gram-positive bacteria, such as:

Folliculitis, furuncles, and carbuncles (caused by Staphylococcus aureus, including some methicillin-sensitive strains).

Cellulitis and erysipelas (caused by Streptococcus pyogenes).

Dosage: Oral tablets (500 mg every 6-8 hours) or topical gels (2% concentration, applied twice daily); typical course duration: 7-14 days.

Anaerobic Infections: Effective for cutaneous anaerobic infections (e.g., necrotizing fasciitis caused by Clostridium perfringens) as an adjunct to surgical debridement. Administered via intravenous (IV) infusion (600 mg every 8 hours).

1.2 Respiratory Tract Infections

Community-Acquired Pneumonia (CAP): Used in penicillin-allergic patients for CAP caused by Streptococcus pneumoniae (penicillin-sensitive) or anaerobic pathogens (e.g., Bacteroides fragilis in aspiration pneumonia). IV dose: 600-1200 mg every 8 hours; switch to oral once clinical improvement is seen.

Pharyngitis & Tonsillitis: Alternative to penicillin for Streptococcus pyogenes-induced pharyngitis in allergic patients (oral dose: 500 mg every 8 hours for 10 days) to prevent post-infectious complications (e.g., rheumatic fever).

1.3 Other Infections

Osteomyelitis & Septic Arthritis: Treats Gram-positive bacterial osteomyelitis (e.g., S. aureus-induced) in patients unable to tolerate penicillins or cephalosporins. IV infusion (600-1200 mg every 8 hours) for 4-6 weeks, followed by oral maintenance.

Pelvic Inflammatory Disease (PID): Adjunctive therapy for anaerobic PID (e.g., caused by Bacteroides spp.) in combination with Gram-negative active antibiotics (e.g., gentamicin). IV dose: 600 mg every 8 hours.

2. Veterinary Field

2.1 Livestock (Cattle, Pigs, Sheep)

Respiratory Tract Infections:

Bovine respiratory disease (BRD) in calves (caused by Mannheimia haemolytica, Staphylococcus aureus): Injectable solution (10 mg/kg body weight, intramuscularly once daily for 3-5 days).

Porcine enzootic pneumonia (PEP) in pigs (caused by Mycoplasma hyopneumoniae and S. aureus): Premixes (2-4 g/kg feed) administered for 7-14 days to control herd outbreaks.

Gastrointestinal Infections:

Porcine proliferative enteropathy (PPE) in growing pigs (adjunctive to other antibiotics): Oral solution (15 mg/kg body weight daily for 5 days) to reduce diarrhea and improve feed conversion.

Sheep foot rot (caused by Dichelobacter nodosus): Topical sprays (5% concentration) or intramuscular injection (10 mg/kg once) to eliminate bacterial load.

2.2 Poultry (Chickens, Turkeys)

Necrotic Enteritis: Controls outbreaks caused by Clostridium perfringens (a major anaerobic pathogen in poultry). Soluble powders (1-2 g/L drinking water) administered for 3-5 days, reducing mortality and improving flock weight gain.

Staphylococcal Infections: Treats Staphylococcus aureus-induced bumblefoot (pododermatitis) in chickens: Injectable dose (20 mg/kg body weight once every 48 hours for 2 doses) combined with wound care.

Quality & Safety Assurance

Lincomycin Hydrochloride's dual use in humans and food-producing animals requires strict quality control, resistance management, and residue monitoring:

Raw Material & Fermentation: For pharmaceutical grade, produced via controlled fermentation of Streptomyces lincolnensis followed by purification (ion exchange chromatography, crystallization) to remove impurities (e.g., lincomycin B ≤2.0%). Veterinary grade uses optimized fermentation parameters to ensure cost-effectiveness while meeting potency standards.

Production Process:

Pharmaceutical-grade products are manufactured in GMP-certified workshops (Class C cleanroom for IV-grade raw materials) with aseptic processing to avoid microbial contamination.

Veterinary-grade premixes/soluble powders undergo particle size optimization (100-200 mesh) to ensure uniform dispersion in feed/water.

Comprehensive Testing Protocol:

Safety Reminders:Human Use:

Contraindications: Hypersensitivity to lincomycin or clindamycin (cross-sensitivity exists); history of pseudomembranous colitis (PMC, a severe intestinal adverse reaction).

Adverse Effects: Gastrointestinal discomfort (nausea, diarrhea), PMC (rare but life-threatening-discontinue if severe diarrhea occurs), and reversible leukopenia (with long-term use).

Veterinary Use:

Withdrawal Periods: Pigs: 5 days (meat), 24 hours (milk); Cattle: 21 days (meat), 72 hours (milk); Chickens: 5 days (meat/eggs).

Resistance Warning: Avoid overuse in livestock (e.g., continuous feed supplementation) to prevent emergence of lincomycin-resistant Staphylococcus or Clostridium strains.

Cooperation & Contact

We supply Lincomycin Hydrochloride in multiple grades and formulations to meet diverse needs:

Pharmaceutical Grade: Raw powder for oral tablets, IV injections, and topical gels (1kg-100kg per order).

Veterinary Grade: Raw powder for premixes, soluble powders, and injectables (10kg-500kg per order, with monthly production capacity of 1000kg).

Value-added services include:

Providing DMF/CEP documents for pharmaceutical-grade products to support registration in the EU, US, and Southeast Asia.

Customized formulation development (e.g., taste-masked oral powders for pediatric use, stable injectable solutions for veterinary use).

Technical guidance on resistance management (for veterinary clients) and adverse reaction monitoring (for pharmaceutical clients).

If you are a pharmaceutical manufacturer, veterinary drug enterprise, or animal feed additive company, please contact us for detailed cooperation:

Contact Information:

Email: sales@huarongpharma.com

Phone/WhatsApp: +86 13751168070

We adhere to the principles of "quality compliance, safety priority, and long-term win-win" and look forward to partnering with global healthcare and animal health enterprises!

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