Vitamin B6 (CAS No.: 8059-24-3) - Essential Water-Soluble Vitamin for Metabolic & Neurological Health
As a professional supplier of pharmaceutical-grade, nutraceutical-grade, and food-grade vitamin ingredients, we provide high-purity Vitamin B6 (a collective term for pyridoxine, pyridoxal, pyridoxamine, and their phosphorylated derivatives) that strictly complies with global standards (USP, EP, FCC, GB). An essential water-soluble B-complex vitamin, it plays a pivotal role in amino acid metabolism, neurotransmitter synthesis, and hemoglobin production. It is widely used in pharmaceutical formulations (for deficiency treatment), nutraceutical supplements (for daily nutrition), and food fortification (for enriched foods)-supporting human health across all age groups.
Product Basic Information
| Item | Details |
|---|---|
| Product Name | Vitamin B6 (Pyridoxine Hydrochloride, the most common commercial form) |
| CAS No. | 8059-24-3 (collective for Vitamin B6 group); Pyridoxine Hydrochloride: 58-56-0 |
| Synonyms | Pyridoxol; 3-Hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine; B6 Vitamin |
| Molecular Formula | C₈H₁₁NO₃·HCl (Pyridoxine Hydrochloride) |
| Molecular Weight | 205.64 (Pyridoxine Hydrochloride) |
| Appearance | White to pale yellow crystalline powder; Odorless, with a slightly bitter taste |
| Specification | - Pharmaceutical Grade: Purity ≥99.0% (HPLC); Assay (as pyridoxine) ≥82.3% (anhydrous basis); Loss on drying ≤0.5%; Heavy metals (Pb≤10ppm, Hg≤1ppm)- Nutraceutical/Food Grade: Purity ≥98.0% (HPLC); Compliant with FCC/GB standards; No artificial additives |
| Melting Point | 205-209°C (Pyridoxine Hydrochloride, with decomposition) |
| Solubility | Freely soluble in water (≥50 g/L at 25°C); Soluble in ethanol; Slightly soluble in acetone; Insoluble in ether, chloroform |
| Storage Conditions | Store in a cool (15-25°C), dry, light-protected container; Avoid exposure to high temperature, moisture, and direct sunlight (prevents degradation); Shelf life: 36 months for pharmaceutical grade, 24 months for nutraceutical/food grade |
Core Functions & Applications
Vitamin B6 is an essential coenzyme for over 100 enzymatic reactions in the human body, primarily involved in amino acid metabolism (transamination, decarboxylation), neurotransmitter synthesis (serotonin, dopamine, GABA), heme production (for hemoglobin), and immune function regulation. Since the human body cannot synthesize it, it must be obtained from external sources. It is applied in three key fields:
1. Pharmaceutical Field (Deficiency Treatment & Therapeutic Support)
1.1 Vitamin B6 Deficiency
Primary Deficiency (rare, caused by inadequate intake): Treats symptoms such as cheilosis (cracked lips), glossitis (inflamed tongue), peripheral neuropathy (tingling in hands/feet), and sideroblastic anemia. Dosage: Oral tablets (25-100 mg daily) for 4-8 weeks until symptoms resolve.
Secondary Deficiency (common, caused by malabsorption, alcoholism, or drug interactions-e.g., isoniazid for tuberculosis): Prophylactic or therapeutic supplementation (50-200 mg daily) to prevent/treat neuropathy and anemia. For isoniazid users, concurrent B6 (10-50 mg daily) is recommended to avoid drug-induced deficiency.
1.2 Neurological Disorders
Peripheral Neuropathy: Adjunctive therapy for diabetic neuropathy or chemotherapy-induced neuropathy (e.g., from paclitaxel). Oral dose: 100-300 mg daily (divided into 3 doses) to alleviate pain and paresthesia, often combined with other B vitamins (B1, B12) for synergistic effects.
Morning Sickness in Pregnancy: Safe for treating severe nausea/vomiting in pregnancy (when dietary adjustments fail). Oral dose: 10-25 mg every 6-8 hours (max 100 mg daily); avoids the risks of antiemetic drugs in early pregnancy.
1.3 Hematological Disorders
Sideroblastic Anemia: Corrects B6-responsive sideroblastic anemia (caused by impaired heme synthesis) by restoring enzyme activity. Initial IV dose (100-200 mg daily) for 1-2 weeks, followed by oral maintenance (50-100 mg daily) to normalize hemoglobin levels.
2. Nutraceutical Field (Daily Nutrition & Wellness Support)
Multivitamin Supplements: A core component of B-complex or multivitamin products (typical dose: 1-10 mg per serving) to meet daily nutritional requirements (adult RDA: 1.3-1.7 mg/day for men, 1.3-1.5 mg/day for women).
Targeted Supplements:
For athletes: Supports protein metabolism and reduces exercise-induced fatigue (often combined with B1, B2, and B3).
For mental health: Adjunct to mood support supplements (due to its role in serotonin/dopamine synthesis) in doses of 10-50 mg daily (under guidance).
For seniors: Prevents age-related B6 deficiency (common in elderly due to reduced absorption) to maintain cognitive function and immune health.
3. Food & Beverage Field (Fortification)
Enriched Foods: Added to cereals (breakfast cereals, oatmeal), bread, and pasta (typical fortification level: 0.5-2 mg/100g) to restore vitamins lost during processing.
Functional Beverages: Included in energy drinks, sports drinks, and nutritional shakes (0.5-1 mg/serving) to support energy metabolism and hydration-related nutrient balance.
Infant Formula: Mandatorily added to infant formula (10-30 μg/100 kcal) to meet the nutritional needs of infants (who cannot obtain sufficient B6 from solid foods).
Quality & Safety Assurance
As an essential nutrient with widespread use in pharmaceuticals, supplements, and food, Vitamin B6 requires rigorous quality control to ensure purity, stability, and safety:
Raw Material & Synthesis: Commercial Vitamin B6 (pyridoxine hydrochloride) is produced via chemical synthesis (condensation of 4-methyl-5-ethoxyoxazole with malonaldehyde diethyl acetal) followed by purification via recrystallization. Raw materials meet USP/EP/FCC standards for impurity limits (e.g., related pyridines ≤0.1%).
Production Process:
Pharmaceutical-grade products are manufactured in GMP-certified workshops (Class D cleanroom for final processing) with automated mixing and drying systems to avoid cross-contamination and ensure batch uniformity.
Nutraceutical/food-grade products undergo additional microbial testing (total aerobic bacteria ≤1000 CFU/g, yeast/mold ≤100 CFU/g) to meet food safety standards.
Comprehensive Testing Protocol:
| Test Item | Method | Acceptance Criterion |
|---|---|---|
| Purity & Assay | HPLC (C18 column, 280 nm detection) | Pharmaceutical grade: ≥99.0% purity, ≥82.3% pyridoxine; Nutraceutical grade: ≥98.0% purity |
| Related Substances | HPLC (gradient elution) | Single impurity ≤0.1%, total impurities ≤0.5% |
| Heavy Metals | ICP-MS (Inductively Coupled Plasma-Mass Spectrometry) | Pb≤10ppm, Hg≤1ppm, Cd≤1ppm |
| Microbial Contamination | Plate count method | Nutraceutical/food grade: Total aerobic bacteria ≤1000 CFU/g, yeast/mold ≤100 CFU/g |
| Identification | IR Spectroscopy & UV Absorption | Matches reference standard spectrum; UV max at 291 nm (in 0.1M HCl) |
Safety Reminders:
Toxicity Risk: Vitamin B6 is generally safe at recommended doses, but long-term high-dose use (>100 mg daily for >6 months) may cause peripheral neuropathy (reversible upon dose reduction). Avoid self-medication with high doses.
Contraindications: Hypersensitivity to pyridoxine or any B6 derivatives; no known contraindications at RDA doses.
Drug Interactions: May interact with levodopa (reduces its efficacy for Parkinson's disease) and oral contraceptives (may increase B6 requirements); consult a healthcare provider if using these drugs.
Cooperation & Contact
We supply Vitamin B6 in multiple grades and formulations to meet diverse application needs:
Pharmaceutical Grade: Raw powder for oral tablets, injections, and topical creams (1kg-100kg per order).
Nutraceutical/Food Grade: Raw powder, granules, or microencapsulated powder (10kg-500kg per order; monthly production capacity of 2000kg) for supplements and food fortification.
Value-added services include:
Providing DMF (Drug Master File) for pharmaceutical-grade products to support client registration in the EU, US, and Asia.
Customized formulations: Microencapsulation (to improve stability in high-temperature food processing) and granulation (for easy blending in supplements).
Technical support: Nutritional dosage guidance (for food/supplement clients) and stability testing data (for pharmaceutical clients).
If you are a pharmaceutical manufacturer, supplement brand, food/beverage producer, or infant formula company, please contact us for detailed cooperation:
Contact Information:
Email: sales@huarongpharma.com
Phone/WhatsApp: +86 13751168070
We adhere to the principles of "purity first, compliance-oriented, and customer-centric" and look forward to partnering with global health and nutrition enterprises!
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