Florfenicol (CAS No.: 73231-34-2) - High-Potency Amphenicol Antibacterial for Veterinary Clinical Use

As a leading supplier of veterinary-grade antibacterial active ingredients, we provide pharmaceutical-grade Florfenicol that strictly adheres to international veterinary pharmacopoeia standards (EP Vet, USP Vet, CP Vet). A synthetic amphenicol derivative optimized for animal health, it addresses the limitations of traditional chloramphenicol (eliminating human hematotoxicity risks) while retaining broad-spectrum antibacterial activity. It is a first-line medication for controlling drug-resistant bacterial infections in livestock, poultry, and aquaculture, playing a critical role in ensuring animal welfare and food safety.

Product Basic Information

Core Functions & Applications

Florfenicol exerts its bacteriostatic (high concentrations show bactericidal effects) activity by specifically binding to the 50S subunit of bacterial ribosomes, inhibiting the formation of peptide bonds during protein synthesis-thus blocking bacterial growth and replication. Its unique chemical structure (fluorine substitution at the phenyl ring) enhances affinity for bacterial ribosomes and resistance to bacterial drug-inactivating enzymes (e.g., chloramphenicol acetyltransferases, CATs), making it effective against chloramphenicol-resistant strains. It is exclusively used in veterinary medicine (no human application) across three core fields:

1. Livestock (Cattle, Pigs, Sheep)

Bovine Respiratory Disease (BRD): The gold-standard treatment for BRD in feedlot cattle, targeting pathogens such as Mannheimia haemolytica (including β-hemolysin-producing strains), Pasteurella multocida, and Histophilus somni. Reduces mortality by 30-50% compared to traditional antibiotics, and relieves severe symptoms (fever ≥40°C, labored breathing) within 24-48 hours.

Porcine Infectious Diseases:

Treats porcine pleuropneumonia caused by Actinobacillus pleuropneumoniae (serotypes 1, 3, 5, 7) and porcine contagious pleuropneumonia, improving survival rates in acute outbreaks.

Controls porcine proliferative enteropathy (PPE) caused by Lawsonia intracellularis-reducing intestinal lesions and restoring feed conversion efficiency (FCE) to normal levels within 7 days.

Dosage Forms:

Injectable formulations (20% w/v suspension): Administered via intramuscular injection (cattle: 20 mg/kg body weight, once every 48 hours, 2 doses total; pigs: 15 mg/kg body weight, once daily, 3 days total).

Premixes (5% or 10% w/w): Mixed into feed for group prevention (pigs: 40-80 mg/kg feed for 7-14 days; sheep: 50-100 mg/kg feed for 5-7 days).

2. Poultry (Chickens, Ducks, Turkeys)

Avian Colibacillosis: Effectively treats systemic colibacillosis in broilers and layers caused by multidrug-resistant Escherichia coli (resistant to ampicillin, tetracycline). Reduces flock mortality from 20-30% to ≤5% and restores egg production in layers within 5 days.

Other Key Infections:

Fowl cholera (caused by Pasteurella multocida): Controls acute outbreaks in turkeys and ducks, with a cure rate of ≥90% when administered early.

Infectious coryza (caused by Haemophilus paragallinarum): Alleviates nasal discharge, facial edema, and respiratory rales in chickens, preventing secondary bacterial infections.

Dosage Form: Soluble powders (10% or 20% w/w): Dissolved in drinking water (broilers: 20-30 mg/kg body weight per day; layers: 15-25 mg/kg body weight per day) for 3-5 consecutive days.

3. Aquaculture (Freshwater & Marine Organisms)

Freshwater Fish Infections:

Treats bacterial septicemia in grass carp, silver carp, and catfish caused by Aeromonas hydrophila and Aeromonas veronii-eliminating symptoms such as skin hemorrhage, fin rot, and abdominal distension.

Controls enteric redmouth disease (ERM) in rainbow trout caused by Yersinia ruckeri, with a therapeutic efficacy of ≥85%.

Marine Aquaculture:

Vibriosis in salmon, sea bass, and shrimp (e.g., Vibrio anguillarum, Vibrio parahaemolyticus): Prevents mass mortality in shrimp ponds and restores feeding activity in infected fish within 48 hours.

Dosage Form:

Feed additives (10% w/w): Mixed into fish/shrimp feed (freshwater fish: 50-75 mg/kg body weight per day; marine fish/shrimp: 75-100 mg/kg body weight per day) for 5-7 days.

Water-soluble powders: Applied via immersion bath (10-20 mg/L water) for 1-2 hours per day for 3 consecutive days (for small-scale fry or ornamental fish).

Quality & Safety Assurance

Florfenicol's application in food-producing animals requires a rigorous quality management system to balance efficacy, resistance control, and residue safety:

Raw Material Control: Uses high-purity chiral intermediates (D-threo-1-(4-fluorophenyl)-2-amino-1,3-propanediol) with a chiral purity of ≥99.5% to avoid the inactive L-threo isomer (which reduces efficacy and may cause tissue irritation). All starting materials meet EU REACH regulations for hazardous substance limits.

Production Process:

Manufactured in a GMP-certified workshop (Class D cleanroom for final product processing) with automated feeding and purification systems to avoid cross-contamination.

The acetylation reaction and crystallization processes are controlled by real-time HPLC monitoring to ensure consistent purity and isomer content across batches.

Comprehensive Testing Protocol:

Safety & Regulatory Compliance:

Residue Control: Complies with global maximum residue limits (MRLs): EU (pork: 200 μg/kg, beef: 300 μg/kg, chicken: 100 μg/kg, fish: 500 μg/kg); China (pork: 200 μg/kg, chicken: 100 μg/kg).

Resistance Mitigation: Provides a "resistance management guide" to clients, recommending combination use with non-amphenicol antibiotics (e.g., florfenicol + probiotics) and avoiding continuous use for more than 14 days.

Species-Specific Warnings: Not for use in dairy cows (may be excreted in milk) or laying hens during the egg-producing period (residues in eggs); Safe for use in pregnant sows (no teratogenicity observed in animal trials).

Cooperation & Contact

We provide Florfenicol in three grades (injectable-grade, premix-grade, aquaculture-grade) to meet diverse veterinary application needs, with supply capacities ranging from 10kg trial orders to 500kg monthly bulk orders. We also offer value-added services:

Customized formulation development (e.g., oil-based suspensions for enhanced injectability, microencapsulated powders for aquaculture).

Regulatory support (providing DMF, CEP documents for client product registration in Europe, Southeast Asia, and Latin America).

Post-sales technical service (on-site guidance for residue testing and dosage optimization).

If you are a veterinary drug manufacturer, feed additive enterprise, or aquaculture technology company, please contact us for detailed cooperation:

Contact Information:

Email: sales@huarongpharma.com

Phone/WhatsApp: +86 13751168070

WeChat: HuarongPharma2023

We adhere to the concept of "win-win cooperation based on quality and compliance" and are committed to becoming a long-term partner for global animal health enterprises!

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