Product Description
Losartan potassium is a white to off-white crystalline powder. It has a distinct chemical structure that gives it its unique pharmacological properties. The molecular formula of losartan potassium is C₂₂H₂₂KNO₅, and it has a molecular weight of 461.52. It is sparingly soluble in water but shows better solubility in certain organic solvents.
Losartan potassium acts by blocking the angiotensin II type 1 (AT1) receptor. Angiotensin II is a hormone that causes blood vessels to constrict, leading to an increase in blood pressure. By blocking the AT1 receptor, losartan potassium prevents the action of angiotensin II, resulting in vasodilation and a reduction in blood pressure.
The primary application of losartan potassium is in the treatment of hypertension. Hypertension, or high blood pressure, is a major risk factor for cardiovascular diseases such as heart attacks, strokes, and kidney failure. Losartan potassium is prescribed to patients with hypertension to help control and manage their blood pressure.
It is also used in the treatment of diabetic nephropathy. In patients with diabetes, high blood pressure can damage the kidneys. Losartan potassium can help protect the kidneys by reducing blood pressure and reducing the amount of protein in the urine.
In addition to its use in these two main areas, losartan potassium may also have potential applications in other conditions. For example, it is being studied for its possible role in the prevention of heart failure and the treatment of certain types of heart disease.
losartan potassium may cause adverse effects. The most common side effects of losartan potassium include headache, dizziness, fatigue, and upper respiratory tract infections. Less common side effects may include diarrhea, nausea, vomiting, muscle pain, and weakness. In rare cases, losartan potassium may cause serious adverse effects such as angioedema, hyperkalemia, and acute renal failure.
Losartan potassium Chemical Properties
|
Melting point |
263-265°C |
|
Storage temp. |
Inert atmosphere, Room Temperature |
|
Solubility |
Freely soluble in water and in methanol, slightly soluble in acetonitrile. |
|
Form |
Powder or crystals |
|
Color |
Off-white |
|
BCS Class |
1 |
|
Stability |
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
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