Product introduction
Telmisartan is an angiotensin receptor blocker (ARB), It is used in the treatment of hypertension also effective in cardiovascular risk reduction.Telmisartan blocks the action of angiotensin II (Ang II), the primary effector molecule of the renin-angiotensin-aldosterone system (RAAS). It is the sixth of this class of 《sartans》 to be marketed after the lead compound Losartan. Its long lasting effect (24h half-life) could be the main difference with other angiotensin II antagonists. Unlike several other agents in this category, its activity does not depend upon transformation into an active metabolite, the 1-O-acylglucuronide being the principal metabolite found in humans. Telmisartan is a potent competitive antagonist of AT1 receptors that mediate most of the important effects of angiotensin II while lacking affinity for the AT2 subtypes or other receptors involved in cardiovascular regulation.
Production specification
|
Telmisartan Chemical Properties |
|
Melting point |
261-263°C |
|
Boiling point |
771.9±70.0 °C(Predicted) |
|
density |
1.16 |
|
RTECS |
DV2037500 |
|
storage temp. |
2-8°C |
|
solubility |
DMSO: >5 mg/mL at 60 °C |
|
form |
solid |
|
pka |
3.86±0.36(Predicted) |
|
color |
white |
|
Water Solubility |
insoluble |
|
Merck |
14,9129 |
|
BCS Class |
2 |
|
Stability: |
Hygroscopic |
|
InChIKey |
RMMXLENWKUUMAY-UHFFFAOYSA-N |
|
SMILES |
C1(C2=CC=C(CN3C(CCC)=NC4=C(C)C=C(C5N(C)C6=CC=CC=C6N=5)C=C43)C=C2)=CC=CC=C1C(O)=O |
|
CAS DataBase Reference |
144701-48-4(CAS DataBase Reference) |
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