Prednisolone (CAS No.: 50-24-8) - Potent Glucocorticoid for Anti-Inflammatory & Immunosuppressive Therapy

As a professional supplier of pharmaceutical-grade steroid active ingredients, we provide high-purity Prednisolone that strictly complies with global pharmacopoeia standards (USP, EP, BP, CP). A synthetic glucocorticoid with stronger anti-inflammatory activity than endogenous hydrocortisone (and lower mineralocorticoid effects), it is a core medication for treating a wide range of inflammatory, allergic, and autoimmune diseases in humans, supporting diverse pharmaceutical formulations.

Product Basic Information

Product Core Functions & Applications

Prednisolone exerts its pharmacological effects by binding to glucocorticoid receptors, inhibiting the release of inflammatory mediators (e.g., prostaglandins, leukotrienes) and suppressing abnormal immune responses. Its stronger anti-inflammatory activity (≈4x that of hydrocortisone) and weak mineralocorticoid effect (minimal impact on water-electrolyte balance) make it suitable for long-term systemic therapy and targeted local treatment. It is mainly applied in human pharmaceutical formulations (veterinary grade available upon request):

1. Systemic Therapy (Oral/Injectable)

Autoimmune Diseases: First-line treatment for conditions like systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren's syndrome, and polymyositis, reducing immune-mediated tissue damage.

Severe Inflammatory Conditions: Manages acute asthma exacerbations, chronic obstructive pulmonary disease (COPD) flare-ups, and inflammatory bowel disease (Crohn's disease, ulcerative colitis) to control acute symptoms.

Hematological Disorders: Used in treating immune thrombocytopenic purpura (ITP), autoimmune hemolytic anemia, and leukemia/lymphoma (as an adjuvant to chemotherapy to reduce inflammation and side effects).

Dosage forms: Oral tablets (for long-term maintenance therapy) and injectable solutions (for emergency cases, e.g., severe allergic reactions, cerebral edema, via intravenous/intramuscular administration).

2. Local & Topical Therapy

Dermatology: Formulated into creams, ointments, and lotions for severe inflammatory skin diseases, such as:

Moderate-to-severe atopic dermatitis, psoriasis (plaque-type)

Allergic contact dermatitis, bullous pemphigoid

Its enhanced anti-inflammatory effect addresses conditions unresponsive to milder steroids (e.g., hydrocortisone).

Ophthalmology: Eye drops/ointments for non-infectious ocular inflammation, including uveitis, keratitis (non-infectious), and post-cataract surgery inflammation, relieving pain and preventing scarring.

Respiratory: Inhalation formulations (aerosols, dry powder inhalers) for long-term control of asthma and COPD, targeting airway inflammation while minimizing systemic side effects.

Quality & Safety Assurance

Prednisolone, as a prescription glucocorticoid with potent activity, requires rigorous quality control to ensure efficacy and reduce safety risks:

Raw Material Sourcing: Uses high-purity starting materials (e.g., hydrocortisone or pregnenolone derivatives) and advanced chemical synthesis (introducing a double bond at C1-2 to enhance activity) to avoid impurities (e.g., related steroids like prednisone) that may affect potency or cause adverse reactions.

Production Process: Manufactured in GMP-certified workshops, with strict control over reaction conditions, purification (e.g., column chromatography), and crystallization to ensure product stability, uniformity, and consistent pharmacological activity.

Testing Protocols: Each batch undergoes comprehensive testing, including:

HPLC analysis for purity and related substances (single impurity ≤1.0%, total impurities ≤3.0%)

Melting point determination (225-231°C, with decomposition)

Specific optical rotation (-102° to -112°, in dioxane)

Heavy metal (Pb, Hg, Cd) and microbial limit testing

Sterility testing (for injectable-grade raw materials)

Safety Reminders:

Long-term systemic use may cause Cushing's syndrome (moon face, truncal obesity), hyperglycemia, osteoporosis, or immunosuppression-must be prescribed by a doctor, with dosage tapered gradually to avoid adrenal insufficiency.

Topical use on large areas or broken skin may lead to systemic absorption; avoid prolonged use on the face or intertriginous areas (e.g., armpits, groin) to reduce skin atrophy risk.

Contraindicated in patients with active infections (e.g., untreated tuberculosis, severe bacterial/viral infections) unless combined with antimicrobial therapy.

Cooperation & Contact

We supply pharmaceutical-grade Prednisolone raw materials for manufacturers of oral, injectable, topical, ophthalmic, and inhalation formulations, with flexible capacities (from gram-level R&D samples to kilogram-level bulk orders). If you are a pharmaceutical enterprise, R&D institution, or formulator in need of this product, please contact us for:

Detailed pharmacopoeia compliance documents (e.g., USP monograph confirmation)

Pricing, bulk order discounts, and sample requests

Technical support (e.g., formulation compatibility, stability studies)

Contact Information:

Email: sales@huarongpharma.com

Phone/WhatsApp: +86 13751168070

We adhere to the principles of "quality first, compliance-oriented" and look forward to establishing long-term, mutually beneficial cooperative relationships with global partners!

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