Product Description
Rabeprazole is a proton pump inhibitor that selectively and irreversibly inhibits the gastric H+/K+ ATPase (IC50 = 72 nM). It can be activated more rapidly and over a greater pH range than other proton pump inhibitors such as omeprazole, lansoprazole, and pantoprazole.
Rabeprazole (30 mg/kg) inhibits gastric acid secretion in pylorus-ligated rats and a rat model of gastric fistula. It also inhibits the growth of several strains of H. pylori in vitro (MIC50s = 1.57-3.13 μg/mL). Formulations containing rabeprazole have been used in the treatment of ulcers, pathological hypersecretory conditions, and gastroesophageal reflux disease (GERD).
Rebeprazole sodium Chemical Properties
|
Melting point |
140-141°C dec. |
|
Solubility |
H2O: soluble10mg/mL (clear solution) |
|
Form |
Powder |
|
Color |
White to beige |
|
Merck |
14,8089 |
|
Stability |
Hygroscopic |
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