Product Description
Sacubitril Valsartan sodium CAS#936623-90-4, is a revolutionary pharmaceutical compound that has significantly impacted the treatment of heart failure. This innovative drug represents a major advancement in the field of cardiology, offering new hope to patients suffering from this debilitating condition.
Heart failure is a complex and serious medical condition that occurs when the heart is unable to pump enough blood to meet the body's needs. It can lead to a wide range of symptoms, including shortness of breath, fatigue, fluid retention, and decreased exercise tolerance. Left untreated, heart failure can progress and lead to serious complications, such as heart attack, stroke, and even death.
Sacubitril Valsartan sodium CAS#936623-90-4 is a combination drug that contains two active ingredients: sacubitril and valsartan. Sacubitril is a neprilysin inhibitor, while valsartan is an angiotensin II receptor blocker. Together, these two compounds work synergistically to provide multiple benefits in the treatment of heart failure.
The mechanism of action of Sacubitril Valsartan sodium CAS#936623-90-4 is complex but highly effective. Sacubitril inhibits the enzyme neprilysin, which is responsible for breaking down natriuretic peptides. By inhibiting neprilysin, sacubitril increases the levels of natriuretic peptides in the body. Natriuretic peptides are hormones that help to relax blood vessels, reduce fluid retention, and lower blood pressure. Valsartan, on the other hand, blocks the action of angiotensin II, a hormone that causes blood vessels to narrow and blood pressure to rise. By blocking angiotensin II, valsartan helps to further relax blood vessels and reduce blood pressure.
The combination of sacubitril and valsartan in Sacubitril Valsartan sodium CAS#936623-90-4 provides several advantages over traditional heart failure medications. First, it has been shown to reduce the risk of hospitalization and death in patients with heart failure. Second, it can improve symptoms such as shortness of breath and fatigue, allowing patients to lead more active lives. Third, it may have a beneficial effect on the structure and function of the heart, potentially slowing the progression of heart failure.
Sacubitril Valsartan sodium CAS#936623-90-4 has several important applications in the treatment of heart failure. It is indicated for the treatment of patients with chronic heart failure with reduced ejection fraction. This means that the drug is used in patients whose hearts are unable to pump out a sufficient amount of blood with each beat. It can be used alone or in combination with other heart failure medications, depending on the patient's specific needs.
In addition to its use in chronic heart failure, Sacubitril Valsartan sodium CAS#936623-90-4 may also have potential applications in other cardiovascular conditions. For example, it is being studied for its possible benefits in patients with heart failure with preserved ejection fraction and in those with hypertension. Further research is needed to determine the full extent of its potential applications.
Sacubitril Valsartan sodium Basic information
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Drugs for heart failure bioactivity In vivo studies |
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Product Name |
Sacubitril Valsartan sodium |
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Synonyms |
Entresto; LZC696; [(C24H29N5O3).(C24H29NO5).2.5(H2O).3Na]; LCZ696 ENTRESTO TM; LCZ696 Entresto; 4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate; Sacubitril mixture with Valsartan; Cocrystal of Sacubitril and Valsartan |
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CAS |
936623-90-4 |
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MW |
847.03 |
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Product Categories |
Cardiovascular Series; Inhibitors; API; 936623-90-4 |
Sacubitril Valsartan sodium Chemical Properties
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Solubility |
≥45.05 mg/mL in DMSO; ≥11.28 mg/mL in H2O; ≥28.5 mg/mL in EtOH |
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Form |
Solid |
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Color |
White to light yellow |
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