Sarafloxacin Hydrochloride CAS 91296-87-6

Mechanism of Action

The mechanism of action of sarafloxacin hydrochloride is based on its ability to inhibit the activity of bacterial DNA gyrase and topoisomerase IV. These enzymes are essential for bacterial DNA replication and transcription. By inhibiting these enzymes, sarafloxacin hydrochloride disrupts bacterial DNA synthesis and leads to the death of the bacteria. This targeted action makes it an effective antibacterial agent against a wide range of bacterial pathogens.

Antibacterial Spectrum

Sarafloxacin hydrochloride has a broad antibacterial spectrum, which means it is effective against a wide variety of bacteria. It is active against both gram-negative and gram-positive bacteria, including some of the most common pathogens that cause infections in animals. Some of the bacteria that are sensitive to sarafloxacin hydrochloride include Escherichia coli, Salmonella spp., Staphylococcus aureus, and Pasteurella multocida. This broad spectrum of activity makes it a valuable tool in the treatment of various bacterial infections in animals.

Veterinary Applications

In veterinary medicine, sarafloxacin hydrochloride is used to treat a wide range of bacterial infections in different animal species. It is commonly used to treat respiratory tract infections, urinary tract infections, gastrointestinal infections, and soft tissue infections. The compound is also used in the prevention and treatment of mastitis in dairy cows. In addition to its antibacterial activity, sarafloxacin hydrochloride may also have some anti-inflammatory and immunomodulatory effects, which can help in the recovery of infected animals.

Safety and Precautions

In animals, the most common side effects include gastrointestinal disturbances, such as vomiting and diarrhea, and allergic reactions. In rare cases, more serious side effects such as neurological disorders and liver damage may occur. To minimize the risks of side effects, it is important to use sarafloxacin hydrochloride according to the recommended dosage and administration guidelines. In addition, the compound should be used with caution in pregnant and lactating animals, as well as in animals with underlying liver or kidney disease.

Storage and Stability

Sarafloxacin hydrochloride should be stored in a cool, dry place away from light and moisture. The compound is relatively stable under normal storage conditions, but it may degrade over time if exposed to extreme temperatures or humidity. It is important to check the expiration date of the product before use and to follow the storage instructions provided by the manufacturer.