Tetracycline Hydrochloride (CAS No.: 64-75-5) - Broad-Spectrum Antibiotic for Bacterial Infection Treatment
As a professional supplier of pharmaceutical and veterinary-grade antibiotics, we provide high-purity Tetracycline Hydrochloride that strictly complies with global pharmacopoeia standards (USP, EP, BP, CP). A classic broad-spectrum tetracycline-class antibiotic, it is widely used in human and veterinary medicine for treating infections caused by susceptible gram-positive, gram-negative bacteria, and certain atypical pathogens, making it a versatile raw material for diverse formulations.
Product Basic Information
| Item | Details |
|---|---|
| Product Name | Tetracycline Hydrochloride |
| CAS No. | 64-75-5 |
| Synonyms | Tetracycline HCl; (4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide hydrochloride |
| Molecular Formula | C₂₂H₂₄N₂O₈·HCl |
| Molecular Weight | 480.90 |
| Appearance | Yellow, crystalline powder; Odorless or with a slight characteristic odor |
| Specification | Pharmaceutical grade / Veterinary grade; Purity ≥90.0% (potency, HPLC); Loss on drying ≤2.0%; Residue on ignition ≤0.5%; Heavy metals ≤20ppm; Compliant with antibiotic impurity and solvent residue limits |
Product Core Functions & Applications
Tetracycline Hydrochloride exerts its antibacterial effect by inhibiting bacterial protein synthesis-binding to the 30S subunit of bacterial ribosomes, preventing aminoacyl-tRNA from attaching to the mRNA-ribosome complex, thereby stopping bacterial growth. Its broad spectrum makes it applicable in both human pharmaceuticals and veterinary medicine:
1. Human Pharmaceutical Field
Respiratory Tract Infections: Treats community-acquired pneumonia, bronchitis, and pharyngitis caused by susceptible pathogens (e.g., Streptococcus pneumoniae, Haemophilus influenzae, atypical pathogens like Mycoplasma pneumoniae).
Skin & Soft Tissue Infections: Effective against impetigo, cellulitis, and acne vulgaris (topical formulations) caused by Staphylococcus aureus or Streptococcus pyogenes.
Other Infections: Used for urinary tract infections (UTIs), sexually transmitted infections (e.g., chlamydia, syphilis in penicillin-allergic patients), and rickettsial diseases (e.g., typhus, Rocky Mountain spotted fever).
Dosage Forms: Raw material for oral formulations (capsules, tablets, syrups) and topical formulations (ointments, eye drops for bacterial conjunctivitis).
2. Veterinary Field (Veterinary-Grade)
Livestock (Cattle, Pigs, Sheep): Controls bacterial infections such as bovine respiratory disease (BRD), swine dysentery, and sheep chlamydiosis; also used to promote growth and improve feed conversion efficiency (in compliant premixes).
Poultry (Chickens, Ducks): Treats avian cholera, infectious coryza, and mycoplasmosis (chronic respiratory disease, CRD), reducing mortality and improving flock health.
Aquaculture: Used in fish and shrimp farming to prevent and treat bacterial diseases (e.g., Aeromonas infections), formulated as soluble powders for water administration.
Common Veterinary Dosage Forms: Premixes, soluble powders, injectables, and oral solutions, designed for easy administration and compliance with veterinary drug residue regulations.
Quality & Safety Assurance
Tetracycline Hydrochloride, as a broad-spectrum antibiotic, requires strict quality control to ensure efficacy, avoid resistance, and prevent residues:
Raw Material Sourcing: Uses high-quality fermentation substrates (for natural tetracycline production) and precise purification processes to remove impurities (e.g., degraded products like 4-epitetracycline) that may reduce potency or cause adverse reactions.
Production Process: Manufactured in GMP-certified workshops, with strict control over fermentation parameters, extraction, crystallization, and hydrochloride salification to ensure product stability and uniform potency.
Testing Protocols: Each batch undergoes comprehensive testing, including:
HPLC analysis for potency, purity, and related substances (e.g., 4-epitetracycline ≤5.0%)
Heavy metal (Pb, Hg, Cd) and arsenic detection
Microbial limit test (for oral/topical grades) and sterility test (for injectable grades)
Residue testing for veterinary-grade products (to meet food safety standards)
Safety Reminders:
Human use: Contraindicated in children under 8 years (may cause tooth discoloration and bone growth inhibition); avoid use in pregnant/nursing women. May cause photosensitivity-patients should avoid excessive sun exposure.
Veterinary use: Strictly follow dosage and withdrawal periods (e.g., 28 days for pigs, 14 days for poultry) to ensure no drug residues in animal products (meat, milk, eggs). Overuse may lead to bacterial resistance.
Cooperation & Contact
We supply Tetracycline Hydrochloride in both pharmaceutical and veterinary grades, with flexible capacities (from gram-level R&D samples to ton-level bulk orders). If you are a pharmaceutical manufacturer, veterinary drug enterprise, or aquaculture supplier in need of this product, please contact us for:
Detailed pharmacopoeia compliance documents and quality certificates
Pricing, bulk discounts, and sample requests
Technical support (e.g., formulation compatibility, stability guidance)
Contact Information:
Email: sales@huarongpharma.com
Phone/WhatsApp: +86 13751168070
We adhere to the principles of "quality first, compliance operation" and look forward to establishing long-term, mutually beneficial cooperative relationships with global partners!
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