Product Description

Salidroside, with the chemical registry number CAS#10338-51-9, is a natural compound that has attracted significant attention in the fields of medicine, health care, and cosmetics due to its remarkable biological activities and potential applications.

Chemical Structure and Properties

Salidroside, also known as rhodioloside, is a glycoside compound. Its chemical structure consists of a tyrosol moiety linked to a glucose molecule. This unique structure endows salidroside with specific physical and chemical properties.

In terms of appearance, salidroside is usually a white to off-white powder. It is moderately soluble in water and some organic solvents. Its stability under different conditions makes it suitable for various processing and storage methods.

Sources and Extraction

Salidroside is mainly found in the plant Rhodiola rosea. Rhodiola rosea is a perennial herbaceous plant that grows in cold and high-altitude regions. The roots and rhizomes of Rhodiola rosea are rich sources of salidroside.

Extraction of salidroside typically involves several methods such as solvent extraction, ultrasonic extraction, and microwave-assisted extraction. These methods aim to efficiently isolate salidroside from the plant material while maintaining its purity and activity.

Biological Activities

Antioxidant Activity

Salidroside exhibits strong antioxidant properties. It can scavenge free radicals and reactive oxygen species (ROS), which are known to cause oxidative damage to cells and tissues. By neutralizing these harmful molecules, salidroside helps protect cells from oxidative stress and reduces the risk of various diseases associated with oxidative damage, such as aging, cancer, and cardiovascular diseases.

For example, in vitro studies have shown that salidroside can protect cells from hydrogen peroxide-induced oxidative damage by increasing the activity of antioxidant enzymes and reducing lipid peroxidation.

Neuroprotective Activity

Salidroside has shown promising neuroprotective effects. It can protect neurons from damage caused by various insults, such as hypoxia, ischemia, and neurotoxicity. Salidroside achieves this by modulating multiple signaling pathways involved in neuronal survival and apoptosis.

For instance, it has been reported that salidroside can improve cognitive function and memory in animal models of Alzheimer's disease by reducing amyloid-beta deposition and inflammation.

Cardioprotective Activity

Salidroside also offers cardioprotective benefits. It can improve cardiac function, reduce myocardial ischemia-reperfusion injury, and prevent the development of cardiovascular diseases. Salidroside exerts these effects by regulating calcium homeostasis, inhibiting oxidative stress, and modulating inflammatory responses.

In clinical studies, salidroside has been shown to improve exercise tolerance and quality of life in patients with chronic heart failure.

Immunomodulatory Activity

Salidroside can modulate the immune system by enhancing immune cell function and reducing inflammation. It can increase the production of cytokines and immunoglobulins, which are important for immune defense. At the same time, salidroside can suppress the activity of pro-inflammatory cytokines and immune cells, thereby reducing inflammation and autoimmune responses.

For example, in animal models of autoimmune diseases, salidroside has been shown to reduce disease severity by modulating the immune response.

Applications

Pharmaceutical Industry

Due to its various biological activities, salidroside has great potential in the pharmaceutical industry. It can be developed into drugs for the treatment of oxidative stress-related diseases, neurodegenerative diseases, cardiovascular diseases, and immune disorders. For example, some research institutes and pharmaceutical companies are currently conducting preclinical and clinical studies on salidroside-based drugs.

Health Care Products

Salidroside is also widely used in health care products. It can be added to dietary supplements, functional foods, and beverages to provide antioxidant, neuroprotective, cardioprotective, and immunomodulatory effects. Consumers can benefit from these products by improving their overall health and well-being.

Cosmetics Industry

In the cosmetics industry, salidroside can be used as an active ingredient in anti-aging and skin care products. Its antioxidant properties can help reduce skin damage caused by free radicals and environmental factors, while its anti-inflammatory effects can soothe and calm the skin. Additionally, salidroside can promote collagen synthesis and improve skin elasticity, making it an ideal ingredient for anti-aging products.

Safety and Toxicity

Studies have shown that salidroside is generally safe and well-tolerated. In animal studies, high doses of salidroside did not cause significant toxicity or adverse effects. However, as with any natural compound, caution should be exercised when using salidroside, especially in pregnant women, lactating women, and people with underlying medical conditions. It is recommended to consult a healthcare professional before using salidroside-based products.

In conclusion, salidroside (CAS#10338-51-9) is a natural compound with diverse biological activities and potential applications. Its antioxidant, neuroprotective, cardioprotective, and immunomodulatory effects make it a promising candidate for the development of drugs, health care products, and cosmetics. With further research and development, salidroside is expected to play an important role in improving human health and quality of life.

Salidroside Basic information

Product Name	Salidroside
CAS	10338-51-9
MF	C14H20O7
MW	300.3
EINECS	695-621-2

Salidroside Chemical Properties

Melting point	159～160℃
Boiling point	549.5±50.0°C (Predicted)
Density	1.46±0.1 g/cm3 (Predicted)
Storage temp.	Sealed in dry, Room Temperature
Solubility	Methanol (Slightly), Pyridine (Slightly)
Form	Solid
Color	Off-White