Thiamine Hydrochloride (Thiamine Chloride Hydrochloride, CAS No.: 67-03-8) - Bioavailable Form of Vitamin B1 for Nutrition & Therapeutics
As a professional supplier of pharmaceutical-grade, nutraceutical-grade, and food-grade vitamin ingredients, we provide high-purity Thiamine Hydrochloride (the most widely used form of Vitamin B1) that strictly complies with global standards (USP, EP, FCC, GB). An essential water-soluble B-complex vitamin, it acts as a key coenzyme in carbohydrate metabolism and neurological function. Its high water solubility and excellent bioavailability make it ideal for pharmaceutical formulations (for rapid deficiency correction), oral supplements, and liquid food fortification-supporting human health across all age groups.
Product Basic Information
| Item | Details |
|---|---|
| Product Name | Thiamine Hydrochloride (Thiamine Chloride Hydrochloride) |
| CAS No. | 67-03-8 |
| Synonyms | Vitamin B1 Hydrochloride; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride hydrochloride |
| Molecular Formula | C₁₂H₁₇N₄O₄S·2HCl |
| Molecular Weight | 337.27 |
| Appearance | White to off-white crystalline powder; Odorless, with a slightly bitter taste |
| Specification | - Pharmaceutical Grade: Purity ≥99.0% (HPLC); Assay (as thiamine) ≥89.0% (anhydrous basis); Loss on drying ≤0.5%; Residue on ignition ≤0.1%; Heavy metals (Pb≤10ppm, Hg≤1ppm, Cd≤1ppm)- Nutraceutical/Food Grade: Purity ≥98.0% (HPLC); Compliant with FCC/GB standards; Microbial count (total aerobic bacteria ≤1000 CFU/g, yeast/mold ≤100 CFU/g) |
| Melting Point | 248-252°C (with decomposition) |
| Solubility | Freely soluble in water (≥100 g/L at 25°C); Soluble in glycerol; Slightly soluble in ethanol; Insoluble in ether, chloroform |
| Storage Conditions | Store in a cool (15-25°C), dry, light-protected container; Avoid exposure to high temperature, moisture, and direct sunlight (prone to degradation under UV light/heat); Shelf life: 36 months for pharmaceutical grade, 24 months for nutraceutical/food grade |
Core Functions & Applications
Thiamine Hydrochloride is biologically active as Vitamin B1, which is converted to thiamine pyrophosphate (TPP)-a critical coenzyme for carbohydrate metabolism (breaking down glucose into ATP for energy) and neurotransmitter synthesis (supporting nerve signal transmission). Unlike thiamine nitrate, its high water solubility enables rapid absorption and distribution in the body, making it the preferred choice for fast-acting therapies and liquid formulations. It is applied in three key fields:
1. Pharmaceutical Field (Deficiency Treatment & Rapid Support)
1.1 Severe Thiamine Deficiency
Wernicke-Korsakoff Syndrome (WKS): A life-threatening neurological disorder (common in alcoholics) characterized by confusion, ataxia, and vision loss. Administered via intravenous (IV) or intramuscular (IM) injection (100 mg daily for 3-7 days) for acute correction, followed by oral maintenance (50-100 mg daily).
Wet Beriberi: A cardiovascular form of deficiency causing edema and heart failure. Initial IV/IM dose (100 mg 2-3 times daily) to stabilize cardiac function, then oral Thiamine Hydrochloride (20-30 mg daily) for long-term management.
1.2 Adjunctive Therapy for Metabolic & Neurological Conditions
Diabetic Neuropathy: Combined with B6 and B12 in oral formulations (50-100 mg Thiamine Hydrochloride per dose) to alleviate nerve pain and paresthesia, leveraging its role in nerve cell energy metabolism.
Post-Surgery Recovery: Added to parenteral nutrition (PN) solutions (5-10 mg daily) for patients unable to eat, preventing iatrogenic thiamine deficiency during carbohydrate-rich IV feeding.
2. Nutraceutical Field (Daily Supplementation)
B-Complex & Multivitamin Supplements: The primary form of Vitamin B1 in oral tablets, capsules, and powdered drinks (typical dose per serving: 1-5 mg) to meet adult RDA (1.1-1.2 mg/day). Its solubility ensures uniform dispersion in liquid supplements (e.g., effervescent tablets, oral drops).
Targeted Supplements:
For individuals with high carbohydrate diets (e.g., athletes, diabetics): 10-20 mg daily to support glucose metabolism and energy production.
For seniors: 5-10 mg daily to address age-related absorption decline and reduce peripheral neuropathy risk.
For alcohol users: 25-50 mg daily to prevent alcohol-induced thiamine depletion.
3. Food & Beverage Field (Fortification)
Liquid Foods & Beverages: Ideal for fortifying milk, plant-based milks (soy, oat), and functional drinks (sports drinks, nutritional shakes) due to its high water solubility. Fortification level: 0.1-0.5 mg/100mL.
Infant Formula & Pediatric Foods: Added to liquid infant formula (10-40 μg/100 kcal) and oral drops for infants, ensuring rapid absorption to meet developmental needs.
Low-Heat Processed Foods: Used in cereals, bread, and snacks processed at moderate temperatures (avoiding high heat to prevent degradation). Fortification level: 0.2-1 mg/100g.
Quality & Safety Assurance
As a widely used essential nutrient, Thiamine Hydrochloride requires rigorous quality control to ensure purity, bioavailability, and safety:
Raw Material & Synthesis: Produced via chemical synthesis (condensation of 4-amino-2-methylpyrimidine with 5-(2-hydroxyethyl)-4-methylthiazole, followed by hydrochlorination) and purified via recrystallization. Raw materials meet USP/EP standards for impurity limits (e.g., thiamine decomposition products ≤0.1%).
Production Process:
Pharmaceutical Grade: Manufactured in GMP-certified workshops (Class D cleanroom for final processing) with inert gas protection during drying to prevent oxidation.
Nutraceutical/Food Grade: Undergoes additional microbial testing and complies with food safety regulations (e.g., FDA 21 CFR for food additives).
Comprehensive Testing Protocol:
| Test Item | Method | Acceptance Criterion |
|---|---|---|
| Purity & Assay | HPLC (C18 column, 246 nm detection) | Pharmaceutical grade: ≥99.0% purity, ≥89.0% thiamine; Nutraceutical grade: ≥98.0% purity |
| Related Substances | HPLC (gradient elution) | Single impurity ≤0.1%, total impurities ≤0.5% |
| Heavy Metals | ICP-MS (Inductively Coupled Plasma-Mass Spectrometry) | Pb≤10ppm, Hg≤1ppm, Cd≤1ppm |
| Microbial Contamination | Plate count method | Nutraceutical/food grade: Total aerobic bacteria ≤1000 CFU/g, yeast/mold ≤100 CFU/g |
| Solubility Test | Gravimetric method | ≥100 g/L in water (25°C), clear solution |
Safety Reminders:
Toxicity: Extremely safe at recommended doses. Even high oral doses (100-500 mg daily) are well-tolerated, with rare mild side effects (nausea, skin flushing).
Contraindications: Hypersensitivity to thiamine or chloride salts (rare); no other known contraindications.
Stability Caution: Degrades under UV light and high heat-avoid prolonged storage in transparent containers or use in high-temperature food processing (opt for thiamine nitrate in such cases).
Cooperation & Contact
We supply Thiamine Hydrochloride in multiple grades and physical forms to meet diverse application needs:
Pharmaceutical Grade: Fine crystalline powder (1kg-100kg per order) for injectables, oral tablets, and parenteral nutrition solutions.
Nutraceutical/Food Grade: Powder or granular form (10kg-500kg per order; monthly production capacity of 2000kg) for supplements, liquid foods, and infant formula.
Value-added services include:
Providing DMF (Drug Master File) and CEP (Certificate of Suitability) for pharmaceutical-grade products to support registration in the EU, US, and Asia.
Customized processing: Micronization (for low-dose tablets) or liquid concentrates (for beverage fortification).
Technical support: Stability data for different formulations and guidance on avoiding degradation in processing.
If you are a pharmaceutical manufacturer, supplement brand, food/beverage producer, or infant formula company, please contact us for detailed cooperation:
Contact Information:
Email: sales@huarongpharma.com
Phone/WhatsApp: +86 13751168070
We adhere to the principles of "purity first, bioavailability priority, and customer satisfaction" and look forward to partnering with global health and nutrition enterprises!
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