Ceftiofur (CAS No.: 80370-57-6) - Third-Generation Cephalosporin Antibacterial for Veterinary Use
As a professional supplier of veterinary-grade antibacterial active ingredients, we provide high-purity Ceftiofur that strictly complies with global veterinary pharmacopoeia standards (USP Vet, EP Vet, CP Vet). A third-generation semi-synthetic cephalosporin, it exhibits broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria-including β-lactamase-producing strains. Exclusive to veterinary practice, it is widely used for treating bacterial infections in livestock (cattle, pigs, sheep) and companion animals (dogs, cats), serving as a critical agent for managing respiratory, urinary, and soft tissue infections while supporting animal health and productivity.
Product Basic Information
| Item | Details |
|---|---|
| Product Name | Ceftiofur |
| CAS No. | 80370-57-6 |
| Synonyms | (6R,7R)-7-[[(2Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetyl]amino]-3-[(2-furylcarbonyl)thiomethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Excenel® (brand name for veterinary formulations) |
| Molecular Formula | C₂₂H₁₉N₅O₇S₃ |
| Molecular Weight | 565.61 |
| Appearance | White to pale yellow crystalline powder; Odorless or with a slight characteristic odor |
| Specification | - Veterinary Grade: Purity ≥95.0% (HPLC); Assay 900–1100 μg/mg (anhydrous basis); Loss on drying ≤2.0%; Residue on ignition ≤0.5%; Heavy metals (Pb≤10ppm, Hg≤1ppm, Cd≤1ppm); Residual solvents (methanol ≤300ppm, acetone ≤500ppm) |
| Melting Point | 170–175°C (with decomposition) |
| Solubility | Slightly soluble in water (≈5 mg/mL at 25°C); Soluble in dilute acids (e.g., 0.1M HCl) and dilute alkalis (e.g., 0.1M NaOH); Slightly soluble in methanol, ethanol; Insoluble in chloroform, ether |
| Storage Conditions | Store in a cool (15–25°C), dry, light-protected container; Sealed to prevent moisture absorption (hygroscopic) and degradation (sensitive to light and high temperatures); Avoid contact with strong oxidizing agents; Shelf life: 24 months for veterinary grade |
Core Functions & Mechanism of Action
CAS# 80370-57-6 exerts a bactericidal effect by interfering with bacterial cell wall synthesis-consistent with the mechanism of cephalosporin-class antibiotics, with key advantages for veterinary pathogens:
Target Binding: Ceftiofur binds to penicillin-binding proteins (PBPs) on the bacterial cell membrane. PBPs are enzymes critical for cross-linking peptidoglycan, the structural backbone of bacterial cell walls.
Cell Wall Disruption: By inhibiting PBP activity, Ceftiofur prevents peptidoglycan cross-linking, leading to weakened cell walls that cannot withstand osmotic pressure.
Bacterial Lysis: Weakened cell walls rupture, causing bacterial cells to lyse (die).
Key antibacterial spectrum advantages for veterinary use:
Gram-Negative Coverage: Highly active against common veterinary pathogens like Mannheimia haemolytica, Pasteurella multocida, Haemophilus somni (cattle), Actinobacillus pleuropneumoniae, Escherichia coli (pigs), and Proteus mirabilis (dogs).
Gram-Positive Coverage: Inhibits susceptible Staphylococcus aureus (MSSA), Streptococcus suis (pigs), and Streptococcus canis (dogs).
β-Lactamase Stability: Resistant to most bacterial β-lactamases (enzymes that inactivate cephalosporins), making it effective against β-lactam-resistant strains common in livestock.
Core Applications (Veterinary Field)
Ceftiofur CAS# 80370-57-6 is administered via injection (IM, SC) or oral formulations (for specific species) and is reserved for treating bacterial infections in animals-never for human use. Dosing varies by species and infection type:
1. Livestock (Cattle, Pigs, Sheep)
1.1 Cattle
Bovine Respiratory Disease (BRD): The most common indication-treats infections caused by Mannheimia haemolytica, Pasteurella multocida, or Haemophilus somni (shipping fever). IM/SC dose: 1.1–2.2 mg/kg body weight once daily for 3–5 days.
Bovine Metritis: Treats post-partum uterine infections caused by E. coli or Arcanobacterium pyogenes. IM dose: 2.2 mg/kg once daily for 3–5 days.
Foot Rot: For bacterial foot infections (e.g., Fusobacterium necrophorum). IM dose: 2.2 mg/kg once daily for 3 days.
1.2 Pigs
Porcine Respiratory Disease Complex (PRDC): Treats infections caused by Actinobacillus pleuropneumoniae, Pasteurella multocida, or Streptococcus suis. IM dose: 3–5 mg/kg once daily for 3–5 days.
Porcine Septicemia: For E. coli or Salmonella-induced bloodstream infections in piglets. IM dose: 5 mg/kg once daily for 3 days.
Swine Dysentery: Adjuvant therapy for Brachiispira hyodysenteriae infections (combined with other antibiotics). IM dose: 3 mg/kg once daily for 3 days.
1.3 Sheep
Ovine Respiratory Disease: Treats Pasteurella multocida or Mannheimia haemolytica infections. IM dose: 2.2 mg/kg once daily for 3–5 days.
Ovine Mastitis: For udder infections caused by Staphylococcus aureus or E. coli. IM dose: 2.2 mg/kg once daily for 3 days.
2. Companion Animals (Dogs, Cats)
Skin & Soft Tissue Infections: Treats pyoderma, abscesses, or cellulitis caused by Staphylococcus pseudintermedius or E. coli. SC dose: 5–10 mg/kg once daily for 5–7 days.
Urinary Tract Infections (UTIs): For E. coli, Proteus mirabilis, or Klebsiella pneumoniae infections. SC dose: 5–10 mg/kg once daily for 7–10 days.
Respiratory Tract Infections: Treats bacterial rhinitis or bronchitis caused by Bordetella bronchiseptica or Pasteurella multocida. SC dose: 5–10 mg/kg once daily for 5–7 days.
3. Contraindications
Do not use in animals hypersensitive to cephalosporins or penicillins (cross-allergy risk).
Avoid use in laying hens (egg residue risk) or dairy cattle producing milk for human consumption (milk residue risk).
Do not use in neonatal animals (under 7 days old) unless directed by a veterinarian (immature renal function increases toxicity risk).
Quality & Safety Assurance
As a veterinary antibiotic critical for animal health and food safety, Ceftiofur requires strict quality control to ensure potency, purity, and compliance with residue limits:
1. Manufacturing & Purity Control
Synthesis: Produced via semi-synthetic modification of 7-ACA (7-aminocephalosporanic acid), with key steps including acylation (adding the aminothiazole side chain) and thiomethylation (forming the furylcarbonyl group). The process ensures:
Minimal impurities (e.g., 7-ACA derivatives, degradation products) ≤2.0% (total impurities);
Consistent β-lactam ring integrity (critical for antibacterial activity), verified via HPLC.
GMP Compliance: Manufactured in Grade D cleanrooms (per ICH Q7 Vet guidelines) with strict control over microbial contamination (total aerobic count ≤100 CFU/g) and endotoxin levels (≤5 EU/mg for injectable formulations).
2. Comprehensive Testing Protocol
| Test Item | Method | Acceptance Criterion |
|---|---|---|
| Purity & Assay | HPLC (C18 column, 254 nm detection) | Purity ≥95.0%; Assay 900–1100 μg/mg |
| Related Substances | HPLC (gradient elution) | Single impurity ≤1.0%; Total impurities ≤2.0% |
| Heavy Metals | ICP-MS (Inductively Coupled Plasma-Mass Spectrometry) | Pb≤10ppm, Hg≤1ppm, Cd≤1ppm |
| Residual Solvents | GC (headspace sampling, FID detector) | Class 2 solvents ≤500ppm; Class 1 solvents not detected |
| Loss on Drying | Gravimetric method (105°C for 2 hours) | ≤2.0% |
| Residue on Ignition | Ashing at 600°C | ≤0.5% |
| Microbial Contamination | Plate count method | Total aerobic count ≤100 CFU/g; No pathogens detected (E. coli, Salmonella) |
3. Safety & Residue Reminders
Animal Safety:
Adverse effects are rare but may include local injection site reactions (swelling, pain) or gastrointestinal upset (diarrhea) in dogs/cats.
Overdose may cause neurotoxicity (tremors, seizures) in small animals-adhere to recommended doses.
Food Safety (Livestock):Withdrawal Periods: Critical to prevent antibiotic residues in animal products:
Cattle: 14 days (meat), 48 hours (milk, if approved for lactating cattle);
Pigs: 5 days (meat);
Sheep: 10 days (meat).
Residue Testing: Compliance with MRLs (Maximum Residue Limits) set by Codex Alimentarius (e.g., 100 μg/kg for ceftiofur residues in cattle meat).
Cooperation & Contact
We supply veterinary-grade CAS# 80370-57-6 in forms tailored to animal-specific formulations:
Veterinary Injectable Grade: Fine powder (1kg–50kg per order, sealed aluminum foil bags with desiccants) for reconstitution into IM/SC injections.
Veterinary Oral Grade: Granules (10kg–200kg per order) for oral premixes (added to feed/water for pigs/sheep).
Value-added services include:
Providing Veterinary Drug Master File (V-DMF) to support regulatory filings in global markets (U.S. FDA CVM, EU EMA, China NMPA).
Technical support for formulation development (e.g., solubility enhancement for injectables, stability testing for premixes).
Batch-specific COA (Certificate of Analysis) with residue testing results to ensure compliance with food safety regulations.
If you are a veterinary drug manufacturer, livestock pharmaceutical supplier, or animal health enterprise, please contact us for detailed cooperation:
Contact Information:
Email: sales@huarongpharma.com
Phone/WhatsApp: +86 13751168070
We adhere to the principles of "veterinary efficacy, food safety, and regulatory compliance" and look forward to partnering with global animal health industries!
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