Colistin Sulfate (CAS No.: 1264-72-8) - Critical Polypeptide Antibiotic for Multidrug-Resistant Bacterial Infections
As a professional supplier of pharmaceutical and veterinary-grade antibiotics, we provide high-purity Colistin Sulfate that strictly complies with global pharmacopoeia standards (USP, EP, BP, CP). A last-resort polypeptide antibiotic, it is primarily used to treat infections caused by multidrug-resistant (MDR) gram-negative bacteria-playing a vital role in human healthcare and veterinary bacterial control, especially when other antibiotics fail.
Product Basic Information
| Item | Details |
|---|---|
| Product Name | Colistin Sulfate |
| CAS No. | 1264-72-8 |
| Synonyms | Polymyxin E Sulfate; Colimycin Sulfate |
| Molecular Formula | C₅₂H₉₈N₁₆O₁₃·2H₂SO₄ (average structure, as a mixture of colistin A and B sulfates) |
| Molecular Weight | ~1400 (average, based on sulfate form) |
| Appearance | White to off-white amorphous powder; Odorless or with a slight characteristic odor |
| Specification | Pharmaceutical grade / Veterinary grade; Potency ≥19,000 IU/mg (HPLC); Loss on drying ≤6.0%; Residue on ignition ≤20.0% (as sulfate); Heavy metals ≤20ppm; Compliant with impurity and endotoxin limits |
Product Core Functions & Applications
Colistin Sulfate exerts its antibacterial effect by disrupting the outer membrane of gram-negative bacteria-binding to lipopolysaccharides (LPS) in the bacterial cell wall, increasing membrane permeability, and causing leakage of cellular contents, ultimately leading to bacterial death. Its narrow spectrum (active only against gram-negative bacteria) and "last-resort" status make it critical in both human medicine and veterinary practice:
1. Human Pharmaceutical Field (Reserved for MDR Infections)
Severe Gram-Negative Infections: Used exclusively for treating life-threatening infections caused by MDR pathogens that are resistant to other antibiotics (e.g., carbapenems), including:
Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) caused by Pseudomonas aeruginosa, Acinetobacter baumannii.
Bloodstream infections (sepsis) and urinary tract infections (UTIs) caused by Klebsiella pneumoniae (carbapenem-resistant, CRKP).
Administration Route: Primarily administered via intravenous (IV) infusion (for systemic infections) or nebulization (for pulmonary infections, to reduce systemic toxicity). Oral formulations are rare in humans (limited to localized intestinal infections).
Key Note: Classified as a "Critically Important Antimicrobial" (WHO) - use is strictly regulated to prevent the development of colistin resistance.
2. Veterinary Field (Veterinary-Grade)
Livestock (Pigs, Cattle, Poultry): Used to prevent and treat enteric infections caused by susceptible gram-negative bacteria, such as:
Porcine colibacillosis (caused by Escherichia coli) - reducing diarrhea and mortality in piglets.
Avian colibacillosis and salmonellosis in chickens/ducks - improving flock health and feed conversion efficiency.
Aquaculture: Effective against bacterial septicemia in fish (e.g., Aeromonas hydrophila, Vibrio parahaemolyticus) and shrimp, formulated as soluble powders for water administration or premixes for feed.
Veterinary Dosage Forms: Premixes, soluble powders, and injectables (for severe systemic infections in livestock), with strict compliance to withdrawal periods to avoid drug residues in animal products.
Quality & Safety Assurance
Colistin Sulfate's status as a last-resort antibiotic and potential nephrotoxicity/neurotoxicity require rigorous quality control:
Raw Material Sourcing: Produced via fermentation of Bacillus polymyxa var. colistinus, with strict control over fermentation conditions to ensure high potency and minimal by-products (e.g., related polypeptides).
Production Process: Manufactured in GMP-certified workshops, with advanced purification (e.g., ion-exchange chromatography) and sulfation processes to remove impurities, endotoxins, and heavy metals-critical for reducing toxicity in human use.
Testing Protocols: Each batch undergoes comprehensive testing, including:
HPLC for potency determination and impurity profiling (to ensure colistin A/B ratio meets standards).
Endotoxin testing (≤0.25 EU/mg for injectable-grade, to prevent pyrogenic reactions).
Heavy metal (Pb, Hg, Cd) and microbial limit testing.
Residue testing for veterinary-grade products (to comply with global food safety regulations, e.g., EU MRLs).
Safety Reminders:
Human use: May cause nephrotoxicity (kidney damage) and neurotoxicity (e.g., numbness, dizziness) - requires dose adjustment based on renal function and close monitoring. Avoid concurrent use with other nephrotoxic drugs (e.g., aminoglycosides).
Veterinary use: Strictly follow dosage guidelines and withdrawal periods (e.g., 7 days for pigs, 5 days for poultry) to prevent residue risks. Overuse is prohibited to avoid the spread of colistin-resistant genes (e.g., mcr-1).
Cooperation & Contact
We supply Colistin Sulfate in both pharmaceutical (human injectable/nebulization grade) and veterinary (premix/soluble powder grade) forms, with flexible capacities (from gram-level R&D samples to ton-level bulk orders). If you are a pharmaceutical manufacturer, veterinary drug enterprise, or aquaculture supplier, please contact us for:
Detailed pharmacopoeia compliance documents, potency certificates, and SDS.
Pricing, bulk discounts, and sample requests (subject to regulatory approval for human-grade).
Technical support (e.g., formulation compatibility, stability guidance).
Contact Information:
Email: sales@huarongpharma.com
Phone/WhatsApp: +86 13751168070
We adhere to the principles of "quality first, responsible use" and look forward to establishing compliant, long-term partnerships with global clients to combat MDR bacterial infections!
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