Flurbiprofen (CAS No.: 5104-49-4) - Potent NSAID for Pain Relief & Anti-Inflammatory Therapy
As a professional supplier of pharmaceutical-grade nonsteroidal anti-inflammatory drugs (NSAIDs), we provide high-purity Flurbiprofen that strictly complies with global pharmacopoeia standards (USP, EP, BP, CP). A potent propionic acid-derived NSAID, it is widely used in human medicine for relieving acute pain, reducing inflammation, and managing chronic arthritic conditions-offering targeted efficacy with well-controlled safety profiles for diverse clinical needs.
Product Basic Information
| Item | Details |
|---|---|
| Product Name | Flurbiprofen |
| CAS No. | 5104-49-4 |
| Synonyms | (±)-2-(2-Fluorobiphenyl-4-yl)propanoic acid; Fluobiprofen |
| Molecular Formula | C₁₅H₁₃FO₂ |
| Molecular Weight | 244.26 |
| Appearance | White or almost white crystalline powder; Odorless or with a slight characteristic odor |
| Specification | Pharmaceutical grade; Purity ≥99.0% (HPLC); Loss on drying ≤0.5%; Residue on ignition ≤0.1%; Heavy metals ≤10ppm; Compliant with solvent residue (e.g., methanol, ethyl acetate) limits |
Product Core Functions & Applications
Flurbiprofen exerts its pharmacological effects by inhibiting cyclooxygenase (COX-1 and COX-2) - key enzymes in the synthesis of prostaglandins (inflammatory mediators). By reducing prostaglandin levels, it effectively alleviates pain, inflammation, and fever. It is exclusively used in human pharmaceutical formulations (no veterinary application) across multiple administration routes:
1. Oral Formulations (Pain & Arthritis Management)
Acute Pain Relief: Treats short-term pain such as post-surgical pain, dental pain, menstrual cramps (dysmenorrhea), and musculoskeletal pain (e.g., sprains, strains) - providing rapid symptom relief within 1-2 hours of administration.
Chronic Arthritic Conditions: Long-term management of rheumatoid arthritis and osteoarthritis, reducing joint swelling, stiffness, and pain to improve mobility and quality of life.
Dosage Forms: Raw material for oral tablets, capsules, and extended-release formulations (to reduce dosing frequency and maintain steady blood levels).
2. Topical Formulations (Localized Pain Relief)
Dermatological & Musculoskeletal Use: Formulated into creams, gels, and patches for localized pain, such as:
Osteoarthritis of the knee, elbow, or hand (targeting joint pain directly).
Soft tissue injuries (e.g., tendonitis, bursitis) and muscle aches.
Key Advantage: Topical application minimizes systemic absorption (reducing gastrointestinal side effects) while delivering drug directly to the pain site.
3. Ophthalmic Formulations (Ocular Inflammation)
Post-Operative Ocular Care: Eye drops for relieving pain, inflammation, and photophobia after cataract surgery or refractive surgery (e.g., LASIK).
Non-Infectious Ocular Conditions: Treats anterior uveitis and allergic conjunctivitis, reducing redness, edema, and discomfort without affecting intraocular pressure (unlike some other NSAIDs).
Quality & Safety Assurance
As an NSAID with potential gastrointestinal and cardiovascular risks, Flurbiprofen requires strict quality control to ensure efficacy and safety:
Raw Material Sourcing: Uses high-purity aromatic precursors (e.g., 2-fluorobiphenyl) and advanced chemical synthesis (propanoic acid derivatization) to avoid impurities (e.g., regioisomers, unreacted starting materials) that may increase toxicity.
Production Process: Manufactured in GMP-certified workshops, with strict control over reaction conditions, purification (e.g., recrystallization), and drying processes to ensure product stability, uniformity, and consistent potency.
Testing Protocols: Each batch undergoes comprehensive testing, including:
HPLC analysis for purity and related substances (single impurity ≤0.1%, total impurities ≤0.5%).
Melting point determination (114-117°C).
Heavy metal (Pb, Hg, Cd) and microbial limit testing (critical for ophthalmic and topical grades).
Assay for optical isomers (for chiral formulations, as S-flurbiprofen is the active enantiomer).
Safety Reminders:
Gastrointestinal Risk: Long-term oral use may cause ulcers or bleeding - avoid in patients with a history of peptic ulcers; concurrent use with proton pump inhibitors (PPIs) is recommended to reduce risk.
Cardiovascular Caution: High doses or prolonged use may increase the risk of heart attack or stroke - use the lowest effective dose for the shortest duration.
Contraindications: Hypersensitivity to NSAIDs (e.g., aspirin-induced asthma), third-trimester pregnancy, and severe renal/hepatic impairment.
Cooperation & Contact
We supply pharmaceutical-grade Flurbiprofen raw materials for manufacturers of oral, topical, and ophthalmic formulations, with flexible capacities (from gram-level R&D samples to kilogram-level bulk orders). If you are a pharmaceutical enterprise, R&D institution, or formulator in need of this product, please contact us for:
Detailed pharmacopoeia compliance documents (e.g., USP/EP monograph confirmation).
Pricing, bulk order discounts, and sample requests.
Technical support (e.g., formulation compatibility, chiral purity guidance).
Contact Information:
Email: sales@huarongpharma.com
Phone/WhatsApp: +86 13751168070
We adhere to the principles of "quality first, patient safety" and look forward to establishing long-term, mutually beneficial cooperative relationships with global pharmaceutical partners!
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