Thiamine Nitrate (CAS No.: 532-43-4) - Stable Form of Vitamin B1 for Nutrition & Therapeutics
As a professional supplier of pharmaceutical-grade, nutraceutical-grade, and food-grade vitamin ingredients, we provide high-purity Thiamine Nitrate (a stable nitrate salt of Vitamin B1) that strictly complies with global standards (USP, EP, FCC, GB). An essential water-soluble B-complex vitamin, Thiamine (Vitamin B1) plays a critical role in carbohydrate metabolism, energy production, and neurological function. Its nitrate salt form offers superior stability compared to thiamine hydrochloride-making it ideal for long-shelf-life supplements, food fortification, and pharmaceutical formulations where resistance to heat, light, and oxidation is required.
Product Basic Information
| Item | Details |
|---|---|
| Product Name | Thiamine Nitrate (Vitamin B1 Nitrate) |
| CAS No. | 532-43-4 |
| Synonyms | 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium nitrate; Vitamin B1 Nitrate; Thiaminium Nitrate |
| Molecular Formula | C₁₂H₁₇N₄O₄S·HNO₃ (or C₁₂H₁₈N₅O₇S) |
| Molecular Weight | 370.37 |
| Appearance | White to off-white crystalline powder or colorless crystals; Odorless, with a slightly bitter taste |
| Specification | - Pharmaceutical Grade: Purity ≥99.0% (HPLC); Assay (as thiamine) ≥75.0% (anhydrous basis); Loss on drying ≤1.0%; Residue on ignition ≤0.1%; Heavy metals (Pb≤10ppm, Hg≤1ppm, Cd≤1ppm)- Nutraceutical/Food Grade: Purity ≥98.0% (HPLC); Compliant with FCC/GB standards; Microbial count (total aerobic bacteria ≤1000 CFU/g, yeast/mold ≤100 CFU/g) |
| Melting Point | 196-200°C (with decomposition) |
| Solubility | Sparingly soluble in water (≈4 g/L at 25°C); Slightly soluble in ethanol; Insoluble in ether, chloroform, benzene |
| Storage Conditions | Store in a cool (15-25°C), dry, light-protected container; Sealed to prevent moisture absorption and oxidation (resists degradation better than thiamine hydrochloride); Shelf life: 36 months for pharmaceutical grade, 24 months for nutraceutical/food grade |
Core Functions & Applications
Thiamine Nitrate exerts the same physiological effects as free thiamine: it acts as a coenzyme (in the form of thiamine pyrophosphate, TPP) in key metabolic pathways-converting carbohydrates into ATP (adenosine triphosphate, the body's energy currency) and supporting the function of the nervous system, cardiovascular system, and digestive tract. Its unique advantage lies in enhanced stability, making it suitable for applications where thiamine hydrochloride would degrade (e.g., high-temperature food processing, long-storage supplements). It is used in three key fields:
1. Pharmaceutical Field (Deficiency Treatment & Therapeutic Support)
1.1 Thiamine Deficiency Disorders
Beriberi: Treats and prevents beriberi (caused by severe thiamine deficiency), including:
Dry beriberi (neurological symptoms: peripheral neuropathy, muscle weakness): Oral dose of 10-30 mg daily for 1-2 months, followed by 5-10 mg daily for maintenance.
Wet beriberi (cardiovascular symptoms: edema, heart failure): Initial parenteral administration (thiamine hydrochloride preferred for rapid absorption) followed by oral Thiamine Nitrate (20-30 mg daily) for long-term management.
Wernicke-Korsakoff Syndrome (WKS): A severe deficiency disorder common in alcoholics (impairs brain function). Used as adjunctive therapy after acute treatment with thiamine hydrochloride-oral Thiamine Nitrate (100 mg daily) prevents relapse and supports neurological recovery.
1.2 Adjunctive Therapy for Metabolic & Neurological Conditions
Diabetic Neuropathy: Combined with other B vitamins (B6, B12) to alleviate nerve pain and paresthesia-oral dose of 50-100 mg daily, leveraging thiamine's role in nerve cell energy metabolism.
Chronic Fatigue Syndrome (CFS): Adjunct to lifestyle interventions to support energy production-20-50 mg daily, particularly for patients with suspected subclinical thiamine deficiency.
2. Nutraceutical Field (Daily Supplementation)
Multivitamin & B-Complex Supplements: The preferred form of Vitamin B1 in long-shelf-life supplements (e.g., tablets, capsules, powdered drinks) due to its stability. Typical dose per serving: 1-5 mg (meets adult RDA of 1.1-1.2 mg/day).
Targeted Supplements:
For athletes: Included in energy-boosting supplements (combined with B2, B3, B6) to support carbohydrate metabolism during high-intensity exercise.
For seniors: Added to age-specific supplements to address age-related thiamine absorption decline and reduce neuropathy risk.
For vegetarians/vegans: Included in plant-based supplements (since thiamine is abundant in animal products) to prevent dietary deficiency.
3. Food & Beverage Field (Fortification)
Heat-Processed Foods: Ideal for fortifying cereals (breakfast cereals, instant oatmeal), bread, and pasta-withstands high-temperature extrusion or baking (where thiamine hydrochloride would degrade). Fortification level: 0.2-1 mg/100g.
Infant Formula & Baby Foods: Mandatorily added to infant formula (10-40 μg/100 kcal) and baby cereals to meet infants' nutritional needs, leveraging its stability during sterilization.
Functional Beverages: Used in shelf-stable energy drinks and nutritional shakes (0.5-2 mg/serving) to avoid thiamine degradation over extended storage periods.
Quality & Safety Assurance
As a critical nutrient with widespread use in pharmaceuticals, supplements, and food, Thiamine Nitrate requires rigorous quality control to ensure purity, stability, and safety:
Raw Material & Synthesis: Produced via chemical synthesis-converting thiamine hydrochloride to thiamine nitrate via ion exchange, followed by recrystallization to remove impurities (e.g., thiamine decomposition products ≤0.1%). Raw materials meet USP/EP/FCC standards for heavy metals and solvent residues.
Production Process:
Pharmaceutical Grade: Manufactured in GMP-certified workshops (Class D cleanroom for final processing) with automated drying systems to control moisture content (≤1.0%, critical for stability).
Nutraceutical/Food Grade: Undergoes additional microbial testing and complies with food safety regulations (e.g., EU Regulation (EC) No. 1129/2011 for food additives).
Comprehensive Testing Protocol:
| Test Item | Method | Acceptance Criterion |
|---|---|---|
| Purity & Assay | HPLC (C18 column, 246 nm detection) | Pharmaceutical grade: ≥99.0% purity, ≥75.0% thiamine; Nutraceutical grade: ≥98.0% purity |
| Related Substances | HPLC (gradient elution) | Single impurity ≤0.1%, total impurities ≤0.5% |
| Heavy Metals | ICP-MS (Inductively Coupled Plasma-Mass Spectrometry) | Pb≤10ppm, Hg≤1ppm, Cd≤1ppm |
| Microbial Contamination | Plate count method | Nutraceutical/food grade: Total aerobic bacteria ≤1000 CFU/g, yeast/mold ≤100 CFU/g |
| Stability Testing | Accelerated stability (40°C/75% RH for 6 months) | No significant purity decline (>95% retention); No color change |
Safety Reminders:
Toxicity: Thiamine Nitrate is extremely safe-no adverse effects reported at recommended doses (RDA or therapeutic doses). Even high doses (100-500 mg daily) are well-tolerated, with rare mild gastrointestinal discomfort.
Contraindications: Hypersensitivity to thiamine or nitrate salts (rare); no other known contraindications.
Drug Interactions: No major interactions with prescription drugs. Avoid concurrent use with high-dose folic acid (may mask thiamine deficiency symptoms)-supplement together if needed.
Cooperation & Contact
We supply Thiamine Nitrate in multiple grades and physical forms to meet diverse application needs:
Pharmaceutical Grade: Fine crystalline powder (1kg-100kg per order) for oral tablets and capsules.
Nutraceutical/Food Grade: Powder or granulated form (10kg-500kg per order; monthly production capacity of 1500kg) for supplements, food fortification, and infant formula.
Value-added services include:
Providing DMF (Drug Master File) and CEP (Certificate of Suitability) for pharmaceutical-grade products to support registration in the EU, US, and Asia.
Customized processing: Micronization (for uniform dispersion in low-dose supplements) or granulation (for easy blending in food products).
Technical support: Stability data for high-temperature processing (for food clients) and dosage guidance (for pharmaceutical/nutraceutical clients).
If you are a pharmaceutical manufacturer, supplement brand, food/beverage producer, or infant formula company, please contact us for detailed cooperation:
Contact Information:
Email: sales@huarongpharma.com
Phone/WhatsApp: +86 13751168070
We adhere to the principles of "quality compliance, stability priority, and customer satisfaction" and look forward to partnering with global health and nutrition enterprises!
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