Physicochemical properties of chloramphenicol

Review: Chloramphenicol, also known as chloramphenicol, is a broad-spectrum antibiotic produced by Streptococcus chloride and has the effect of inhibiting bacterial growth. Natural chloramphenicol is a levo-rotary body. The synthetic product is white or slightly yellow needle-like or flaky crystals, odorless, extremely bitter, slightly soluble in water, ether and chloroform, easily soluble in methanol, ethanol, acetone or ethyl acetate, insoluble in benzene and petroleum ether. It is relatively stable in neutral or weakly acidic aqueous solutions, but easily fails when exposed to alkali. It can effectively prevent and treat bacterial diseases such as aquatic product rot, erythroderma, enteritis, etc. However, the drug is highly toxic to humans. It inhibits the hematopoietic function of the bone marrow, causing allergic reactions and aplastic anemia. Long-term consumption of large amounts of animal-derived chloramphenicol residues Food may cause intestinal flora imbalance and inhibit the formation of antibodies.
Density: 1.474g/cm3
Melting point: 148-150℃
Boiling point: 563.2
Refractive index: 1.623
Flash point: 294.4℃
Appearance: white crystalline powder
Solubility: Slightly soluble in water, slightly soluble in propylene glycol, easily soluble in methanol, ethanol, butanol, ethyl acetate, acetone, insoluble in ether, benzene, petroleum ether, vegetable oil.