Production Method Of 2-chloro-4-aminopyridine

The preparation method is to use isonicotinic acid as a raw material, chlorine it with phosphorus oxychloride to obtain 2-chloropyridine-4-carboxylic acid, react it with ammonia gas to generate the corresponding amide, and then perform a Hoffmann degradation reaction to obtain the product. You can also use 2-chloropyridine-N-oxide as raw material, first use fuming nitric acid for nitration, and then use iron powder to reduce it in acetic acid to obtain the product.