Products Description

5-Hydroxytryptophan, also known as 5-HTP, with the chemical registry number CAS#56-69-9, is a naturally occurring amino acid derivative that has gained significant attention in the field of health and wellness due to its potential therapeutic benefits.

Chemical Structure and Properties

5-HTP is chemically derived from the amino acid tryptophan. It is synthesized in the body from tryptophan through a series of enzymatic reactions. The chemical structure of 5-HTP consists of an indole ring, a carboxyl group, and an amino group.

In terms of physical properties, 5-HTP is a white to off-white crystalline powder. It is sparingly soluble in water and more soluble in organic solvents such as ethanol and methanol. 5-HTP has a melting point of around 298-300°C.

Sources and Biosynthesis

5-HTP is naturally found in certain plants, such as the seeds of the Griffonia simplicifolia plant. This plant is native to West and Central Africa and is the main source of commercial 5-HTP.

In the human body, 5-HTP is synthesized from tryptophan. Tryptophan is obtained through the diet and is converted to 5-hydroxytryptophan by the enzyme tryptophan hydroxylase. This enzyme is rate-limiting in the synthesis of serotonin, a neurotransmitter that plays a crucial role in mood regulation, sleep, appetite, and other physiological functions.

Biological Activities

Mood Enhancement

One of the main biological activities of 5-HTP is its ability to enhance mood. Serotonin is known as the "feel-good" neurotransmitter, and low levels of serotonin have been associated with depression, anxiety, and other mood disorders. By increasing the synthesis of serotonin, 5-HTP may help improve mood and reduce symptoms of depression and anxiety.

Several studies have shown that 5-HTP is effective in treating mild to moderate depression. It may be as effective as some antidepressant medications, but with fewer side effects.

Appetite Regulation

Serotonin plays a role in appetite regulation, and 5-HTP may help reduce appetite and promote weight loss. By increasing serotonin levels, 5-HTP may signal the brain to feel full and reduce food intake.

Some studies have shown that 5-HTP may be effective in reducing appetite and promoting weight loss, especially when combined with a healthy diet and exercise.

Sleep Promotion

5-HTP also has a role in promoting sleep. Serotonin is converted to melatonin, a hormone that regulates the sleep-wake cycle. By increasing serotonin levels, 5-HTP may indirectly increase melatonin production and improve sleep quality.

Some people use 5-HTP as a natural sleep aid to treat insomnia and other sleep disorders.

Pain Relief

5-HTP may also have analgesic properties. Serotonin is involved in the modulation of pain signals, and increasing serotonin levels may help reduce pain.

Some people use 5-HTP to treat chronic pain conditions such as fibromyalgia and migraines.

Applications

Dietary Supplements

5-HTP is widely available as a dietary supplement. It is often sold in capsule, tablet, or powder form. Dietary supplements containing 5-HTP are marketed for their mood-enhancing, sleep-promoting, appetite-regulating, and pain-relieving properties.

However, it is important to note that dietary supplements are not regulated in the same way as medications. The quality and purity of dietary supplements can vary, and there is a risk of interactions with other medications or supplements.

Pharmaceuticals

5-HTP is also being investigated as a potential pharmaceutical agent. Some studies have shown that 5-HTP may be effective in treating certain neurological and psychiatric disorders, such as depression, anxiety, and obsessive-compulsive disorder.

However, more research is needed to determine the safety and efficacy of 5-HTP as a pharmaceutical drug.

Safety and Toxicity

When taken as directed, 5-HTP is generally considered safe. However, like any supplement or medication, it can cause side effects in some people. Common side effects of 5-HTP include nausea, diarrhea, headache, and dizziness.

In rare cases, 5-HTP can cause more serious side effects, such as serotonin syndrome. Serotonin syndrome is a potentially life-threatening condition that occurs when there is an excess of serotonin in the body. Symptoms of serotonin syndrome include agitation, confusion, rapid heart rate, high blood pressure, and muscle rigidity.

People taking 5-HTP should be aware of the potential for side effects and should consult a healthcare professional before taking this supplement. Additionally, 5-HTP may interact with certain medications, such as antidepressants, so it is important to inform your healthcare provider of all medications and supplements you are taking.

In conclusion, 5-hydroxytryptophan (CAS#56-69-9) is a naturally occurring amino acid derivative with potential therapeutic benefits. Its ability to enhance mood, promote sleep, regulate appetite, and relieve pain makes it an attractive option for people looking for natural alternatives to medications. However, more research is needed to fully understand its safety and efficacy, and it should be used with caution and under the guidance of a healthcare professional.

5-Hydroxytryptophan Basic information

Product Name	5-Hydroxytryptophan
CAS	56-69-9
MF	C11H12N2O3
MW	220.22
EINECS	200-284-8

5-Hydroxytryptophan Chemical Properties

Melting point	298-300°C
Boiling point	361.16°C (rough estimate)
Density	1.484
Storage temp.	Keep in dark place, Sealed in dry, Room Temperature
Solubility	DMSO (Slightly), Methanol (Slightly)
Form	Solid
Color	Off-White to Pale Beige
Water Solubility	Soluble in water (4 mg/ml at 25°C), methanol.