Product Description
Alpha-bisabolol, with the chemical registry number CAS#515-69-5, is a natural compound that has gained significant attention in the fields of cosmetics, pharmaceuticals, and aromatherapy due to its numerous beneficial properties.
Chemical Structure and Properties
Alpha-bisabolol is a sesquiterpene alcohol with the chemical formula C₁₅H₂₆O. It has a unique chemical structure consisting of three isoprene units. The compound is colorless to pale yellow in appearance and has a mild, pleasant odor.
Alpha-bisabolol is sparingly soluble in water but highly soluble in organic solvents such as ethanol, ether, and chloroform. It has a relatively low melting point and a high boiling point. These physical properties make it suitable for various applications in different industries.
Sources and Extraction
Alpha-bisabolol is found in several natural sources, particularly in the essential oils of certain plants. One of the main sources is the chamomile plant, especially Matricaria chamomilla (German chamomile) and Matricaria recutita (Roman chamomile). Other plants that contain alpha-bisabolol include candeia tree (Eremanthus erythropappus) and some species of the Asteraceae family.
The extraction of alpha-bisabolol from these plants is typically done through steam distillation or solvent extraction. Steam distillation involves passing steam through the plant material to vaporize the essential oils, which are then condensed and separated. Solvent extraction uses an organic solvent to dissolve the essential oils from the plant material. The extracted essential oils are then further processed to isolate and purify alpha-bisabolol.
Biological Activities
Anti-inflammatory Activity
Alpha-bisabolol has potent anti-inflammatory properties. It can inhibit the production of inflammatory mediators such as prostaglandins, leukotrienes, and cytokines. This makes it useful in the treatment of various inflammatory conditions, including skin inflammation, gastrointestinal inflammation, and respiratory inflammation.
For example, in dermatology, alpha-bisabolol is often used in skincare products to soothe irritated skin and reduce redness. It can also help in the treatment of eczema, psoriasis, and other inflammatory skin disorders.
Antioxidant Activity
Alpha-bisabolol is a strong antioxidant. It can scavenge free radicals and reactive oxygen species (ROS), which are responsible for oxidative damage to cells and tissues. By neutralizing these harmful molecules, alpha-bisabolol helps protect cells from oxidative stress and reduces the risk of various diseases associated with oxidative damage, such as cancer, cardiovascular diseases, and neurodegenerative disorders.
In cosmetics, alpha-bisabolol is added to anti-aging products to help prevent premature skin aging caused by oxidative stress.
Wound Healing Activity
Alpha-bisabolol has been shown to promote wound healing. It can stimulate the proliferation of skin cells and enhance the synthesis of collagen, a protein that is essential for wound closure and tissue repair. Additionally, alpha-bisabolol has antibacterial and antifungal properties, which can help prevent wound infections.
In the pharmaceutical industry, alpha-bisabolol is being investigated as a potential wound healing agent for the treatment of burns, cuts, and ulcers.
Analgesic Activity
Alpha-bisabolol has mild analgesic (pain-relieving) properties. It can reduce pain by inhibiting the transmission of pain signals in the nervous system. This makes it useful in the treatment of mild to moderate pain, such as headaches, muscle aches, and menstrual cramps.
In aromatherapy, alpha-bisabolol is often used in essential oil blends for its soothing and pain-relieving effects.
Applications
Cosmetics and Skincare Products
Alpha-bisabolol is widely used in cosmetics and skincare products due to its beneficial properties for the skin. It is commonly found in facial creams, lotions, serums, and sunscreens. It can help soothe irritated skin, reduce redness, and protect the skin from oxidative stress. Additionally, alpha-bisabolol can improve the texture and appearance of the skin, making it look more smooth and radiant.
For example, some high-end skincare brands use alpha-bisabolol as a key ingredient in their anti-aging products.
Pharmaceuticals
Alpha-bisabolol has potential applications in the pharmaceutical industry. It is being investigated as a treatment for various inflammatory conditions, wound healing, and pain relief. Additionally, alpha-bisabolol may have anticancer properties and is being studied for its potential use in cancer therapy.
In some countries, alpha-bisabolol is already used in over-the-counter medications for the treatment of minor skin irritations and burns.
Aromatherapy
Alpha-bisabolol is used in aromatherapy for its calming and relaxing effects. It is often added to essential oil blends and diffusers to create a soothing atmosphere. The pleasant odor of alpha-bisabolol can help reduce stress, anxiety, and insomnia.
For example, a blend of chamomile essential oil containing alpha-bisabolol can be used in a diffuser before bedtime to promote relaxation and improve sleep quality.
Safety and Toxicity
Alpha-bisabolol is generally considered safe for use in cosmetics, pharmaceuticals, and aromatherapy. It has a low toxicity profile and is well-tolerated by the skin and body. However, as with any natural product, some individuals may be allergic or sensitive to alpha-bisabolol.
In cosmetics and skincare products, alpha-bisabolol is typically used in low concentrations and is considered safe for most people. In pharmaceuticals, the safety and efficacy of alpha-bisabolol are evaluated through clinical trials.
It is important to note that pregnant women, nursing mothers, and individuals with certain medical conditions should consult a healthcare professional before using products containing alpha-bisabolol.
In conclusion, alpha-bisabolol (CAS#515-69-5) is a natural compound with a wide range of beneficial properties. Its anti-inflammatory, antioxidant, wound healing, and analgesic activities make it a valuable ingredient in cosmetics, pharmaceuticals, and aromatherapy. As research continues to uncover more of its potential applications, alpha-bisabolol is likely to play an increasingly important role in these industries.
alpha-Bisabolol Basic information
|
Product Name |
Alpha-Bisabolol |
|
CAS |
515-69-5 |
|
MF |
C15H26O |
|
MW |
222.37 |
|
EINECS |
208-205-9 |
alpha-Bisabolol Chemical Properties
|
Melting point |
25°C |
|
Boiling point |
154-156°C |
|
Density |
0.93g/mL at 20°C (lit.) |
|
Fp |
135°C |
|
Storage temp. |
Refrigerator |
|
Form |
Liquid |
|
Color |
Clear Colourless |
|
Odor |
At 100.00%. mild floral peppery balsamic clean |
|
Odor Type |
Floral |
|
Water Solubility |
Soluble in alcohol, natural, mineral and synthetic oils. Insoluble in water. |
|
Stability |
Stable. Combustible. Incompatible with strong oxidizing agents. |
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