Product Description
Beta-nicotinamide mononucleotide (NMN), with the chemical registry number CAS#1094-61-7, is a molecule that has gained significant attention in the scientific community and the health and wellness industry due to its potential role in promoting healthy aging and improving various aspects of human health.
Chemical Structure and Properties
NMN is a nucleotide that consists of a nicotinamide moiety, a ribose sugar, and a phosphate group. Its chemical structure is similar to that of nicotinamide adenine dinucleotide (NAD+), a coenzyme that plays a crucial role in cellular metabolism.
In terms of physical properties, NMN is a white crystalline powder that is soluble in water. It is relatively stable under normal conditions but may degrade under certain environmental factors such as heat and light.
Sources and Biosynthesis
NMN can be found in small amounts in some foods, such as broccoli, cabbage, cucumber, and avocado. However, the levels of NMN in these foods are relatively low, and it is difficult to obtain sufficient amounts through diet alone.
In the body, NMN is synthesized from nicotinamide (vitamin B3) through a series of enzymatic reactions. The enzyme nicotinamide phosphoribosyltransferase (NAMPT) plays a key role in this process by converting nicotinamide and 5-phosphoribosyl-1-pyrophosphate (PRPP) to NMN.
Biological Activities
Role in NAD+ Biosynthesis
The primary biological activity of NMN is its role in the biosynthesis of NAD+. NAD+ is an essential coenzyme that participates in numerous cellular processes, including energy metabolism, DNA repair, and gene expression. As we age, the levels of NAD+ in the body decline, which has been associated with various age-related diseases and functional decline.
By supplementing with NMN, it is possible to increase the levels of NAD+ in the body, which may help to counteract the effects of aging and improve cellular function.
Anti-Aging Effects
There is growing evidence to suggest that NMN may have anti-aging effects. Studies in animals have shown that NMN supplementation can improve various markers of aging, such as mitochondrial function, insulin sensitivity, and immune function. Additionally, NMN has been shown to extend the lifespan of certain organisms.
Although the mechanisms underlying the anti-aging effects of NMN are not fully understood, it is thought that its ability to increase NAD+ levels and improve cellular metabolism may play a role.
Metabolic Benefits
NMN has also been shown to have beneficial effects on metabolism. It can improve insulin sensitivity, reduce blood sugar levels, and increase energy expenditure. These effects may be beneficial for the prevention and treatment of metabolic disorders such as type 2 diabetes and obesity.
The metabolic benefits of NMN are likely due to its effects on mitochondrial function and energy metabolism. By improving the efficiency of energy production in cells, NMN may help to maintain normal metabolic function.
Neurological Benefits
There is some evidence to suggest that NMN may have beneficial effects on the nervous system. It has been shown to protect neurons from oxidative stress and inflammation, and may improve cognitive function and memory. Additionally, NMN may have potential as a treatment for neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
The neurological benefits of NMN may be related to its ability to increase NAD+ levels and improve mitochondrial function in neurons.
Applications
Dietary Supplements
Due to its potential health benefits, NMN is available as a dietary supplement. These supplements are typically sold in capsule or powder form and are marketed for their anti-aging, metabolic, and neurological benefits.
However, it is important to note that the safety and efficacy of NMN supplements have not been fully established, and more research is needed to determine the optimal dosage and long-term effects.
Research Tool
NMN is also widely used as a research tool in the laboratory. It is used to study the role of NAD+ in cellular metabolism and aging, and to investigate potential therapeutic strategies for age-related diseases.
By manipulating the levels of NMN and NAD+ in cells and animals, researchers can gain insights into the mechanisms underlying aging and disease and develop new treatments.
Safety and Toxicity
Although NMN is generally considered safe, there is still limited data on its long-term safety and toxicity. Some studies have reported mild side effects such as nausea, headache, and fatigue in some individuals taking NMN supplements.
As with any supplement or drug, it is important to consult with a healthcare professional before taking NMN, especially if you have underlying medical conditions or are taking medications. Additionally, more research is needed to determine the optimal dosage and potential interactions with other substances.
In conclusion, beta-nicotinamide mononucleotide (NMN) is a molecule with significant potential for promoting healthy aging and improving various aspects of human health. Its role in NAD+ biosynthesis, anti-aging effects, metabolic benefits, and neurological benefits have made it a subject of intense research in recent years. While more research is needed to fully understand its mechanisms of action and long-term safety, NMN holds promise as a potential therapeutic agent for age-related diseases and a dietary supplement for maintaining optimal health.
β-Nicotinamide Mononucleotide Basic information
|
Product Name |
β-Nicotinamide Mononucleotide |
|
CAS |
1094-61-7 |
|
MF |
C11H15N2O8P |
|
MW |
334.22 |
|
EINECS |
214-136-5 |
|
Mol File |
1094-61-7.mol |
β-Nicotinamide Mononucleotide Chemical Properties
|
Melting point |
166°C (dec.) |
|
Storage temp. |
-20°C |
|
Solubility |
DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly) |
|
Form |
Solid |
|
Color |
White to Yellow |
|
Stability |
Very Hygroscopic |
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