Adverse reactions of heparin sodium

1. Bleeding is the most common and may occur anywhere.
2. Chills, fever, urticaria and other allergic reactions are common.
3. Long-term medication can cause hair loss, short-term reversible alopecia, osteoporosis and spontaneous fractures.
4. Local irritation, erythema, slight headache, hematoma, ulcer, etc. may be seen at the injection site. It is more serious after intramuscular injection, so intramuscular injection is not suitable.
5. Transient thrombocytopenia is still seen. Heparin-induced thrombocytopenia (HIT) is caused by the binding of heparin-platelet factor 4 antibody complex to the platelet factor 4 receptor. Can activate platelet aggregation and cause arteriolar embolism. Although rare, it can be fatal. If HIT occurs, heparin should be discontinued immediately.